Show simple item record

dc.contributor.authorLim, David
dc.contributor.authorFlicker, L.
dc.contributor.authorDharamarajan, A.
dc.contributor.authorMartins, R.
dc.date.accessioned2017-01-30T14:10:33Z
dc.date.available2017-01-30T14:10:33Z
dc.date.created2011-11-29T20:01:06Z
dc.date.issued2003
dc.identifier.citationLim, David and Flicker, Leon and Dharamarajan, Arunasalam and Martins, Ralph N. 2003. Can testosterone replacement decrease the memory problem of old age? Medical Hypotheses. 60 (6): pp. 893-896.
dc.identifier.urihttp://hdl.handle.net/20.500.11937/37988
dc.identifier.doi10.1016/S0306-9877(03)00072-0
dc.description.abstract

The world is rapidly ageing. It is against this backdrop that there are increasing incidences of dementia reported worldwide, with Alzheimer's disease (AD) being the most common form of dementia in the elderly. It is estimated that AD affects almost 4 million people in the US, and costs the US economy more than 65 million dollars annually. There is currently no cure for AD but various therapeutic agents have been employed in attempting to slow down the progression of the illness, one of which is oestrogen. Over the last decades, scientists have focused mainly on the roles of oestrogen in the prevention and treatment of AD. Newer evidences suggested that testosterone might also be involved in the pathogenesis of AD. Although the exact mechanisms on how androgen might affect AD are still largely unknown, it is known that testosterone can act directly via androgen receptor-dependent mechanisms or indirectly by converting to oestrogen to exert this effect. Clinical trials need to be conducted to ascertain the putative role of androgen replacement in Alzheimer's disease.

dc.publisherChurchill Livingston
dc.titleCan testosterone replacement decrease the memory problem of old age?
dc.typeJournal Article
dcterms.source.volume60
dcterms.source.number6
dcterms.source.startPage893
dcterms.source.endPage896
dcterms.source.issn03069877
dcterms.source.titleMedical Hypotheses
curtin.departmentSchool of Public Health
curtin.accessStatusFulltext not available


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record