Role of phospholipase C in cell invasion and metastasis
dc.contributor.author | Lattanzio, R. | |
dc.contributor.author | Piantelli, M. | |
dc.contributor.author | Falasca, Marco | |
dc.date.accessioned | 2017-01-30T14:16:36Z | |
dc.date.available | 2017-01-30T14:16:36Z | |
dc.date.created | 2015-10-29T04:09:34Z | |
dc.date.issued | 2013 | |
dc.identifier.citation | Lattanzio, R. and Piantelli, M. and Falasca, M. 2013. Role of phospholipase C in cell invasion and metastasis. Advances in Biological Regulation. 53 (3): pp. 309-318. | |
dc.identifier.uri | http://hdl.handle.net/20.500.11937/38308 | |
dc.identifier.doi | 10.1016/j.jbior.2013.07.006 | |
dc.description.abstract |
Phospholipases are enzymes that use phospholipids as substrate and are classified in three major classes A, C and D based on the reaction they catalyse. Phosphatidylinositol-specific Phospholipase C enzymes utilize phosphatidylinositol 4,5-bisphosphate as substrate and cleave the bond between the glycerol and the phosphate to produce important second messenger such as inositol trisphosphate and diacylglycerol. The Phospholipase C members are the most well-known phospholipases for their role in lipid signalling and cell proliferation and comprise 13 isoforms classified in 6 distinct sub-families. In particular, signalling activated by Phospholipase C γ, mostly activated by receptor and non-receptor tyrosine kinases, is well characterized in different cell systems. Increasing evidence suggest that Phospholipase C γ plays a key role in cell migration and invasion. Because of its role in cell growth and invasion, aberrant Phospholipase C γ signalling can contribute to carcinogenesis. A major challenge facing investigators who seek to target Phospholipase C γ directly is the fact that it is considered an “undruggable” protein. Indeed, isoform specificity and toxicity represents a big hurdle in the development of Phospholipase C γ small molecule inhibitors. Therefore, a future development in the field could be the identification of interacting partners as therapeutic targets that could be more druggable than Phospholipase C γ. | |
dc.title | Role of phospholipase C in cell invasion and metastasis | |
dc.type | Journal Article | |
dcterms.source.volume | 53 | |
dcterms.source.number | 3 | |
dcterms.source.startPage | 309 | |
dcterms.source.endPage | 318 | |
dcterms.source.issn | 2212-4926 | |
dcterms.source.title | Advances in Biological Regulation | |
curtin.department | School of Biomedical Sciences | |
curtin.accessStatus | Fulltext not available |
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