Nucleic-acid recognition interfaces: How the greater ability of RNA duplexes to bend towards the surface influences electrochemical sensor performance

Tavallaie, R.; Darwish, Nadim; Brynn Hibbert, D.; Justin Gooding, J.

doi:10.1039/c5cc05450h

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Access Status

Open access

Authors

Tavallaie, R.

Darwish, Nadim

Brynn Hibbert, D.

Justin Gooding, J.

Date

2015

Type

Journal Article

Metadata

Show full item record

Citation

Tavallaie, R. and Darwish, N. and Brynn Hibbert, D. and Justin Gooding, J. 2015. Nucleic-acid recognition interfaces: How the greater ability of RNA duplexes to bend towards the surface influences electrochemical sensor performance. Chemical Communications. 51 (92): pp. 16526-16529.

Source Title

Chemical Communications

DOI

10.1039/c5cc05450h

ISSN

1359-7345

Faculty

Faculty of Science and Engineering

School

Nanochemistry Research Institute

Remarks

This open access article is distributed under the Creative Commons license http://creativecommons.org/licenses/by-nc/3.0/

URI

http://hdl.handle.net/20.500.11937/38493

Collection

Curtin Research Publications

Abstract

The influence of RNA versus DNA on the performance of electrochemical biosensors where redox-labelled nucleic acid duplexes bend towards the electrode surface has been assessed. Faster electron transfer was observed for duplexes containing RNA, suggesting duplexes with RNA are more flexible. These data are of particular importance for microRNA biosensors.