Non-Hfe iron overload: Is phlebotomy the answer?
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Non-Hfe Iron Overload: Is Phlebotomy the Answer?Iron is an essential factor for life, however a physiologically optimal balance is critical. In this article we explore the role of iron as a co-factor in a range of chronic liver diseases and how it may contribute to the development of liver injury, fibrosis, cirrhosis and ultimately hepatocellular carcinoma. Whilst iron depletion therapy through phlebotomy is the most effective method of reducing iron stores, it is unclear whether this offers utility in the therapy of liver diseases in which iron is not the primary insult resulting in tissue injury. Here we examine the emerging evidence in the field of non-HFE hereditary haemochromatosis conditions associated with iron overload – is phlebotomy the answer?
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The impact of phlebotomy in nonalcoholic fatty liver disease: A prospective, randomized, controlled trialAdams, L.; Crawford, D.; Stuart, K.; House, M.; St Pierre, T.; Webb, M.; Ching, H.; Kava, J.; Bynevelt, M.; Macquillan, G.; Garas, G.; Ayonrinde, Oyekoya; Mori, T.; Croft, K.; Niu, X.; Jeffrey, G.; Olynyk, John (2015)Iron is implicated in the pathogenesis of liver injury and insulin resistance (IR) and thus phlebotomy has been proposed as a treatment for nonalcoholic fatty liver disease (NAFLD). We performed a prospective 6-month ...
Nadakkavukaran, I.; Gan, E.; Olynyk, John (2012)Hereditary haemochromatosis (HH) is a common autosomal recessive disorder of iron overload in Caucasian populations. Clinical manifestations usually occur in individuals homozygous for the C282Y mutation in the HFE gene ...
Adris, N.; Hazeldine, S.; Bentley, P.; Trinder, D.; Chua, A.; Powell, L.; Ramm, L.; Ramm, G.; Olynyk, John (2018)Detection of HFE Haemochromatosis (HH) is challenging in the absence of clinical features. HH subjects have elevated erythrocyte parameters compared to those without HH, but it remains unclear how this could be applied ...