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dc.contributor.authorDolgova, N.
dc.contributor.authorHackett, Mark
dc.contributor.authorMacDonald, T.
dc.contributor.authorNehzati, S.
dc.contributor.authorJames, A.
dc.contributor.authorKrone, P.
dc.contributor.authorGeorge, G.
dc.contributor.authorPickering, I.
dc.date.accessioned2017-01-30T14:23:24Z
dc.date.available2017-01-30T14:23:24Z
dc.date.created2016-11-20T19:31:21Z
dc.date.issued2016
dc.identifier.citationDolgova, N. and Hackett, M. and MacDonald, T. and Nehzati, S. and James, A. and Krone, P. and George, G. et al. 2016. Distribution of selenium in zebrafish larvae after exposure to organic and inorganic selenium forms. Metallomics. 8 (3): pp. 305-312.
dc.identifier.urihttp://hdl.handle.net/20.500.11937/38597
dc.identifier.doi10.1039/c5mt00279f
dc.description.abstract

Selenium is an essential micronutrient for many organisms, and in vertebrates has a variety of roles associated with protection from reactive oxygen species. Over the past two decades there have been conflicting reports upon human health benefits and detriments arising from consumption of selenium dietary supplements. Thus, early studies report a decrease in the incidence of certain types of cancer, whereas subsequent studies did not observe any anti-cancer effect, and adverse effects such as increased risks for type 2 diabetes have been reported. A possible contributing factor may be that different chemical forms of selenium were used in different studies. Using larval stage zebrafish (Danio rerio) as a model organism, we report a comparison of the toxicities and tissue selenium distributions of four different chemical forms of selenium. We find that the organic forms of selenium tested (Se-methyl-l-selenocysteine and l-selenomethionine) show considerably more toxicity than inorganic forms (selenite and selenate), and that this appears to be correlated with the level of bioaccumulation. Despite differences in concentrations, the tissue specific pattern of selenium accumulation was similar for the chemical forms tested; selenium was found to be highly concentrated in pigment (melanin) containing tissues especially for the organic selenium treatments, with lower concentrations in eye lens, yolk sac and heart. These results suggest that pigmented tissues might serve as a storage reservoir for selenium. © 2016 The Royal Society of Chemistry.

dc.rights.urihttp://creativecommons.org/licenses/by-nc/3.0/
dc.titleDistribution of selenium in zebrafish larvae after exposure to organic and inorganic selenium forms
dc.typeJournal Article
dcterms.source.volume8
dcterms.source.number3
dcterms.source.startPage305
dcterms.source.endPage312
dcterms.source.issn1756-5901
dcterms.source.titleMetallomics
curtin.departmentDepartment of Chemistry
curtin.accessStatusOpen access


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