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    Cardiorespiratory fitness levels and their association with cardiovascular profile in patients with rheumatoid arthritis: a cross-sectional study

    234877_234877.pdf (282.4Kb)
    Access Status
    Open access
    Authors
    Metsios, G.
    Koutedakis, Y.
    Veldhuijzen van Zanten, J.
    Stavropoulos-Kalinoglou, A.
    Vitalis, P.
    Duda, J.
    Ntoumanis, Nikos
    Rouse, P.
    Kitas, G.
    Date
    2015
    Type
    Journal Article
    
    Metadata
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    Citation
    Metsios, G. and Koutedakis, Y. and Veldhuijzen van Zanten, J. and Stavropoulos-Kalinoglou, A. and Vitalis, P. and Duda, J. and Ntoumanis, N. et al. 2015. Cardiorespiratory fitness levels and their association with cardiovascular profile in patients with rheumatoid arthritis: a cross-sectional study. Rheumatology. 54 (12): pp. 2215-2220.
    Source Title
    Rheumatology
    DOI
    10.1093/rheumatology/kev035
    School
    School of Psychology and Speech Pathology
    URI
    http://hdl.handle.net/20.500.11937/3868
    Collection
    • Curtin Research Publications
    Abstract

    Objective. The aim of this study was to investigate the association of different physical fitness levels [assessed by the maximal oxygen uptake (VO2max) test] with cardiovascular disease (CVD) risk factors in patients with RA. Methods. A total of 150 RA patients were assessed for cardiorespiratory fitness with a VO2max test and, based on this, were split in three groups using the 33rd (18.1 ml/kg/min) and 66th (22.4 ml/kg/min) centiles. Classical and novel CVD risk factors [blood pressure, body fat, insulin resistance, cholesterol, triglycerides, high-density lipoprotein (HDL), physical activity, CRP, fibrinogen and white cell count], 10-year CVD risk, disease activity (DAS28) and severity (HAQ) were assessed in all cases. Results. Mean VO2max for all RA patients was 20.9 (s.d. 5.7) ml/kg/min. The 10-year CVD risk (P = 0.003), systolic blood pressure (P = 0.039), HDL (P = 0.017), insulin resistance and body fat (both at P < 0.001), CRP (P = 0.005), white blood cell count (P = 0.015) and fibrinogen (P < 0.001) were significantly different between the VO2max tertiles favouring the group with the higher VO2max levels. In multivariate analyses of variance, VO2max was significantly associated with body fat (P < 0.001), HDL (P = 0.007), insulin resistance (P < 0.003) and 10-year CVD risk (P < 0.001), even after adjustment for DAS28, HAQ and physical activity. Conclusion. VO2max levels are alarmingly low in RA patients. Higher levels of VO2max are associated with a better cardiovascular profile in this population. Future studies need to focus on developing effective behavioural interventions to improve cardiorespiratory fitness in RA.

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