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    Colorectal cancer biomarkers: To be or not to be? Cautionary tales from a road well travelled

    Access Status
    Open access via publisher
    Authors
    Fung, K.
    Nice, E.
    Priebe, I.
    Belobrajdic, D.
    Phatak, Aloke
    Purins, L.
    Tabor, B.
    Pompeia, C.
    Lockett, T.
    Adams, T.
    Burgess, A.
    Cosgrove, L.
    Date
    2014
    Type
    Journal Article
    
    Metadata
    Show full item record
    Citation
    Fung, K. and Nice, E. and Priebe, I. and Belobrajdic, D. and Phatak, A. and Purins, L. and Tabor, B. et al. 2014. Colorectal cancer biomarkers: To be or not to be? Cautionary tales from a road well travelled. World Journal of Gastroenterology. 20 (4): pp. 888-898.
    Source Title
    World Journal of Gastroenterology
    DOI
    10.3748/wjg.v20.i4.888
    ISSN
    1007-9327
    School
    Department of Mathematics and Statistics
    URI
    http://hdl.handle.net/20.500.11937/3878
    Collection
    • Curtin Research Publications
    Abstract

    Colorectal cancer (CRC) is the second most common cause of cancer-related death worldwide and places a major economic burden on the global health care system. The time frame for development from premalignant to malignant disease typically spans 10-15 years, and this latent period provides an ideal opportunity for early detection and intervention to improve patient outcomes. Currently, early diagnosis of CRC is hampered by a lack of suitable non-invasive biomarkers that are clinically or economically acceptable for population-based screening. New blood-based protein biomarkers for early detection of CRC are therefore urgently required. The success of clinical biomarker discovery and validation studies is critically dependent on understanding and adjusting for potential experimental, analytical, and biological factors that can interfere with the robust interpretation of results. In this review we outline some important considerations for research groups undertaking biomarker research with exemplars from our studies. Implementation of experimental strategies to minimise the potential effects of these problems will facilitate the identification of panels of biomarkers with the sensitivity and specificity required for the development of successful tests for the early detection and surveillance of CRC.

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