Are drug-eluting stents indicated in large coronary arteries? Insights from a multi-centre percutaneous coronary intervention registry
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Background: Restenosis rates are low in large coronary vessels = 3.5 mm after bare-metal stent (BMS) implantation. The benefit of drug-eluting stents (DES) in large vessels is not established. Objective: We aim to assess clinical outcomes after deployment of BMS compared to DES in patients with large coronary vessels = 3.5 mm. Methods: We analysed 672 consecutive patients undergoing percutaneous coronary interventions with = 3.5 mm stent implantation in native coronary artery de-novo lesions from the Melbourne Interventional Group (MIG) registry. Baseline characteristics, 30-day and 12-month outcomes of patients receiving BMS were compared to DES. Multivariate analysis was performed to identify predictors of major adverse cardiac events [MACE, consisting of death, myocardial infarction (MI) and target vessel revascularisation (TVR)]. Results: Of the 672 PCIs performed in 844 lesions, DES was implanted in 39.5% (n = 333) and BMS in 60.5% (n = 511) of lesions. Patients who received DES compared to BMS were older, more likely to be diabetic, had left ventricular dysfunction < 45% or complex lesions. Significantly fewer patients who presented with ST-elevation MI received DES compared to BMS. There were no significant differences in 12-month mortality (0.5 vs. 2.9%, p = 0.07), TVR (3.6 vs. 4.8%, p = 0.54), MI (6.3 vs. 3.4%, p = 0.15), stent thrombosis (0.9 vs. 1.0%, p = 0.88), or MACE (9.4 vs. 9.4%, p = 0.90) in patients who received DES vs. BMS. Stent length = 20 mm was the only independent predictor of 12-month MACE (Odds Ratio 2.07, 95% CI 1.14-3.76, p = 0.02). Conclusion: In this registry, BMS implantation in large native coronary vessels = 3.5 mm was associated with a low risk of MACE and repeat revascularization at 12 months that was comparable to DES. © 2008 Elsevier Ireland Ltd. All rights reserved.
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