Curtin University Homepage
  • Library
  • Help
    • Admin

    espace - Curtin’s institutional repository

    JavaScript is disabled for your browser. Some features of this site may not work without it.
    View Item 
    • espace Home
    • espace
    • Curtin Research Publications
    • View Item
    • espace Home
    • espace
    • Curtin Research Publications
    • View Item

    The Australian Imaging, Biomarkers and Lifestyle (AIBL) study of aging: methodology and baseline characteristics of 1112 individuals recruited for a longitudinal study of Alzheimer’s disease

    Access Status
    Fulltext not available
    Authors
    Ellis, K.
    Bush, A.
    Darby, D.
    de Fazio, D.
    Foster, Jonathan
    Hudson, P.
    Lautenschlager, N.
    Lenzo, N.
    Martins, R.
    Maruff, P.
    Masters, C.
    Milner, A.
    Pike, K.
    Rowe, C.
    Savage, G.
    Szoeke, C.
    Taddei, K.
    Villemagne, V.
    Woodward, M.
    Ames, D.
    Acosta, O.
    Ames, J.
    Agarwal, M.
    Bahar-Fuchs, A.
    Baxendale, D.
    Bechta-Metti, K.
    Bevage, C.
    Bevege, L.
    Bourgeat, P.
    Brown, B.
    Bush, A.
    Clarnette, R.
    Cowie, T.
    Crowley, K.
    Currie, A.
    El- Sheikh, D.
    Ellis, K.
    Dickinson, K.
    Farrow, M.
    Faux, N.
    Fripp, J.
    Fowler, C.
    Gupta, V.
    Jones, G.
    Khoo, J.
    Killedar, A.
    Killeen, N.
    Kim, T.W.
    Kotsopoulos, E.
    Lachovitzki, R.
    Lautenschlager, N.
    Li, Q.
    Liang, X.
    Lucas, K.
    Lui, J.
    Martins, G.
    Martins, R.
    Montague, C.
    Moore, L.
    Muir, A.
    O’Halloran, C.
    O’Keefe, G.
    Panayiotou, A.
    Paton, A.
    Paton, J.
    Peiffer, J.
    Pejoska, S.
    Pertile, K.
    Porter, L.
    Price, R.
    Raniga, P.
    Rees, G.
    Rembach, A.
    Rimajova, M.
    Robins, P.
    Ronsisvalle, E.
    Rumble, R.
    Rodrigues, M.
    Salvado, O.
    Sach, J.
    Samuel, M.
    Sittironnarit, G.
    Taddei, T.
    Trivedi, D.
    Trounson, B.
    Tsikkos, M.
    Walker, S.
    Ward, V.
    Yastrubetskaya, O.
    Date
    2009
    Type
    Journal Article
    
    Metadata
    Show full item record
    Citation
    Ellis, K. and Bush, A. and Darby, D. and de Fazio, D. and Foster, J. and Hudson, P. and Lautenschlager, N. et al. 2009. The Australian Imaging, Biomarkers and Lifestyle (AIBL) study of aging: methodology and baseline characteristics of 1112 individuals recruited for a longitudinal study of Alzheimer’s disease. International Psychogeriatrics. 21 (4): pp. 672-687.
    Source Title
    International Psychogeriatrics
    DOI
    10.1017/S1041610209009405
    ISSN
    1041-6102
    URI
    http://hdl.handle.net/20.500.11937/39114
    Collection
    • Curtin Research Publications
    Abstract

    Background: The Australian Imaging, Biomarkers and Lifestyle (AIBL) flagship study of aging aimed to recruit 1000 individuals aged over 60 to assist with prospective research into Alzheimer's disease (AD). This paper describes the recruitment of the cohort and gives information about the study methodology, baseline demography, diagnoses, medical comorbidities, medication use, and cognitive function of the participants. Methods: Volunteers underwent a screening interview, had comprehensive cognitive testing, gave 80 ml of blood, and completed health and lifestyle questionnaires. One quarter of the sample also underwent amyloid PET brain imaging with Pittsburgh compound B (PiB PET) and MRI brain imaging, and a subgroup of 10% had ActiGraph activity monitoring and body composition scanning. Results: A total of 1166 volunteers were recruited, 54 of whom were excluded from further study due to comorbid disorders which could affect cognition or because of withdrawal of consent. Participants with AD (211) had neuropsychological profiles which were consistent with AD, and were more impaired than participants with mild cognitive impairment (133) or healthy controls (768), who performed within expected norms for age on neuropsychological testing. PiB PET scans were performed on 287 participants, 100 had DEXA scans and 91 participated in ActiGraph monitoring. Conclusion: The participants comprising the AIBL cohort represent a group of highly motivated and well-characterized individuals who represent a unique resource for the study of AD. They will be reassessed at 18-month intervals in order to determine the predictive utility of various biomarkers, cognitive parameters and lifestyle factors as indicators of AD, and as predictors of future cognitive decline.

    Related items

    Showing items related by title, author, creator and subject.

    • Do images of a personalised future body shape help with weight loss? A randomised controlled study
      Ossolinski, G.; Jiwa, M.; McManus, Alexandra; Parsons, R. (2017)
      Background: This randomised controlled study evaluated a computer-generated future self-image as a personalised, visual motivational tool for weight loss in adults. Methods: One hundred and forty-five people (age 18-79 ...
    • Utility of an Alzheimer's Disease Risk-Weighted Polygenic Risk Score for Predicting Rates of Cognitive Decline in Preclinical Alzheimer's Disease: A Prospective Longitudinal Study.
      Porter, T.; Burnham, S.; Milicic, L.; Savage, G.; Maruff, P.; Lim, Y.; Li, Q.; Ames, D.; Masters, C.; Rainey-Smith, S.; Rowe, C.; Salvado, O.; Groth, D.; Verdile, Giuseppe; Villemagne, V.; Laws, S.; AIBL Research Group (2018)
      BACKGROUND: With the exception of APOE, genetic variants associated with increased Alzheimer's disease (AD) risk are characterized by small effect sizes. Polygenic risk scores (PRS) have shown utility in predicting AD ...
    • A Polygenic Risk Score Derived From Episodic Memory Weighted Genetic Variants Is Associated With Cognitive Decline in Preclinical Alzheimer's Disease
      Porter, T.; Burnham, S.; Savage, G.; Lim, Y.; Maruff, P.; Milicic, L.; Peretti, M.; Ames, D.; Masters, C.; Martins, R.; Rainey-Smith, S.; Rowe, C.; Salvado, O.; Taddei, K.; Groth, David; Verdile, Giuseppe ; Villemagne, V.; Laws, Simon (2018)
      Studies of Alzheimer's disease risk-weighted polygenic risk scores (PRSs) for cognitive performance have reported inconsistent associations. This inconsistency is particularly evident when PRSs are assessed independent ...
    Advanced search

    Browse

    Communities & CollectionsIssue DateAuthorTitleSubjectDocument TypeThis CollectionIssue DateAuthorTitleSubjectDocument Type

    My Account

    Admin

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular Authors

    Follow Curtin

    • 
    • 
    • 
    • 
    • 

    CRICOS Provider Code: 00301JABN: 99 143 842 569TEQSA: PRV12158

    Copyright | Disclaimer | Privacy statement | Accessibility

    Curtin would like to pay respect to the Aboriginal and Torres Strait Islander members of our community by acknowledging the traditional owners of the land on which the Perth campus is located, the Whadjuk people of the Nyungar Nation; and on our Kalgoorlie campus, the Wongutha people of the North-Eastern Goldfields.