Curtin University Homepage
  • Library
  • Help
    • Admin

    espace - Curtin’s institutional repository

    JavaScript is disabled for your browser. Some features of this site may not work without it.
    View Item 
    • espace Home
    • espace
    • Curtin Research Publications
    • View Item
    • espace Home
    • espace
    • Curtin Research Publications
    • View Item

    Effect of coadministered fat on the tolerability, safety and pharmacokinetic properties of dihydroartemisinin-piperaquine in Papua New Guinean children with uncomplicated malaria

    Access Status
    Open access via publisher
    Authors
    Moore, Brioni
    Benjamin, J.
    Salman, S.
    Griffin, S.
    Ginny, E.
    Page-Sharp, Madhu
    Robinson, L.
    Siba, P.
    Batty, Kevin
    Mueller, I.
    Davis, T.
    Date
    2014
    Type
    Journal Article
    
    Metadata
    Show full item record
    Citation
    Moore, B. and Benjamin, J. and Salman, S. and Griffin, S. and Ginny, E. and Page-Sharp, M. and Robinson, L. et al. 2014. Effect of coadministered fat on the tolerability, safety and pharmacokinetic properties of dihydroartemisinin-piperaquine in Papua New Guinean children with uncomplicated malaria. Antimicrobial Agents and Chemotherapy. 58 (10): pp. 5784-5794.
    Source Title
    Antimicrobial Agents and Chemotherapy
    DOI
    10.1128/AAC.03314-14
    ISSN
    0066-4804
    School
    School of Pharmacy
    URI
    http://hdl.handle.net/20.500.11937/3926
    Collection
    • Curtin Research Publications
    Abstract

    Coadministration of dihydroartemisinin-piperaquine (DHA-PQ) with fat may improve bioavailability and antimalarial efficacy, but it might also increase toxicity. There have been no studies of these potential effects in the pediatric age group. The tolerability, safety, efficacy, and pharmacokinetics of DHA-PQ administered with or without 8.5 g fat were investigated in 30 Papua New Guinean children aged 5 to 10 years diagnosed with uncomplicated falciparum malaria. Three daily 2.5:11.5-mg-base/kg doses were given with water (n = 14, group A) or milk (n = 16, group B), with regular clinical/laboratory assessment and blood sampling over 42 days. Plasma PQ was assayed by high-performance liquid chromatography with UV detection, and DHA was assayed using liquid chromatography-mass spectrometry. Compartmental pharmacokinetic models for PQ and DHA were developed using a population-based approach. DHA-PQ was generally well tolerated, and initial fever and parasite clearance were prompt. There were no differences in the areas under the concentration-time curve (AUC0–∞) for PQ (median, 41,906 versus 36,752 μg • h/liter in groups A and B, respectively; P = 0.24) or DHA (4,047 versus 4,190 μg • h/liter; P = 0.67). There were also no significant between-group differences in prolongation of the corrected electrocardiographic QT interval (QTc) initially during follow-up, but the QTc tended to be higher in group B children at 24 h (mean ± standard deviation [SD], 15 ± 10 versus 6 ± 15 ms0.5 in group A, P = 0.067) and 168 h (10 ± 18 versus 1 ± 23 ms0.5, P = 0.24) when plasma PQ concentrations were relatively low. A small amount of fat does not change the bioavailability of DHA-PQ in children, but a delayed persistent effect on ventricular repolarization cannot be excluded.

    Related items

    Showing items related by title, author, creator and subject.

    • A randomised comparison trial to evaluate an in-home parent-directed drug education intervention
      Beatty, Shelley Ellen (2003)
      The long-term regular use of tobacco and hazardous alcohol use are responsible for significant mortality and morbidity as well as social and economic harm in Australia each year. There is necessary the more cost-efficient ...
    • Language Outcomes of 7-Year-Old Children With or Without a History of Late Language Emergence at 24 Months
      Rice, M.; Taylor, Catherine; Zubrick, Stephen (2008)
      Purpose: The aim of this study was to investigate the language outcomes of 7-year-old children with and without a history of late language emergence at 24 months.Method: One hundred twenty-eight children with a history ...
    • Impact of family integrated care on infants' clinical outcomes in two children's hospitals in China: A pre-post intervention study
      He, S.; Xiong, Y.; Zhu, L.; Lv, B.; Gao, X.; Xiong, H.; Wang, H.; Shi, H.; Latour, Jos (2018)
      © 2018 The Author(s). Background: Most Neonatal Intensive Care Units (NICUs) in China have restricted visiting policies for parents. This also implicates that parents are not involved in the care of their infant. Family ...
    Advanced search

    Browse

    Communities & CollectionsIssue DateAuthorTitleSubjectDocument TypeThis CollectionIssue DateAuthorTitleSubjectDocument Type

    My Account

    Admin

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular Authors

    Follow Curtin

    • 
    • 
    • 
    • 
    • 

    CRICOS Provider Code: 00301JABN: 99 143 842 569TEQSA: PRV12158

    Copyright | Disclaimer | Privacy statement | Accessibility

    Curtin would like to pay respect to the Aboriginal and Torres Strait Islander members of our community by acknowledging the traditional owners of the land on which the Perth campus is located, the Whadjuk people of the Nyungar Nation; and on our Kalgoorlie campus, the Wongutha people of the North-Eastern Goldfields.