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    Pain Controlling and Cytokine-regulating Effects of Lyprinol, a Lipid Extract of Perna canaliculus, in a Rat Adjuvant-Induced Arthritis Model

    Access Status
    Open access via publisher
    Authors
    Lee, C.
    Lum, J.
    Ng, Curtise
    McKay, Janice
    Butt, Y.
    Wong, M.
    Lo, S.
    Date
    2007
    Type
    Journal Article
    
    Metadata
    Show full item record
    Citation
    Lee, Chi-Ho and Lum, John and Ng, Curtise and McKay, Janice and Butt, Yoki and Wong, Man-Sau and Lo, Samuel. 2007. Pain Controlling and Cytokine-regulating Effects of Lyprinol, a Lipid Extract of Perna canaliculus, in a Rat Adjuvant-Induced Arthritis Model. Evidence-Based Complementary and Alternative Medicine. 6 (2): pp. 239-245.
    Source Title
    Evidence-Based Complementary and Alternative Medicine
    DOI
    10.1093/ecam/nem100
    ISSN
    1741-427X
    Faculty
    School of Science and Computing
    Faculty of Science and Engineering
    Department of Imaging and Applied Physics
    URI
    http://hdl.handle.net/20.500.11937/39321
    Collection
    • Curtin Research Publications
    Abstract

    Using an adjuvant-induced arthritis rat model, we investigated the effects of a lipid extract of Perna canaliculus (Lyprinol) on pain. Radiological examinations, as well as levels of pro- and anti-inflammatory (AI) cytokines, were measured aiming to provide independent objective data to the pain controlling investigation. We confirmed the ability of Lyprinol to control pain at the initial phase of its administration; with similar efficacy to that observed with Naproxen. The pain scores slowly increased again in the group of rats treated with Lyprinol after day 9-14.The Naproxen-treated rats remained pain-free while treated. Both Naproxen and Lyprinol decreased the levels of the pro-inflammatory cytokines TNF-a and IFN-g, and increased that of IL-10. Extra-virgin olive oil was ineffective on cytokine secretion. Rats treated with Lyprinol were apparently cured after 1 year. This study confirms the AI efficacy of this lipid extract of P.canaliculus, its initial analgesic effect, its perfect tolerance and its long-term healing properties.

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