Syringomyelia and the fluid-structure interactions of a cerebrospinal waveguide
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In the disease syringomyelia, fluid-filled cavities, called syrinxes, form in the spinal cord. The expansion of these pathological pressure vessels compresses the surrounding nerve fibers and blood supply, which is associated with neurological damage. We investigate the spinal wave-propagation characteristics, principally to serve as a reference for more anatomically-detailed models. The spinal cord is modeled as an elastic cylinder, which becomes an annulus containing inviscid fluid when a syrinx is included. This is surrounded by an annulus of in-viscid fluid, representing the cerebrospinal fluid occupying the subarachnoid space, with an outer rigid boundary approximating the dura mater. The axisymmetric harmonic motion is solved as an eigenvalue problem. We present dispersion diagrams and describe the physical mechanism of each wave mode. We identify potentially damaging syrinx fluid motions and tissue stress concentrations from the eigenvectors. Finally, we determine the dependence of each wave mode on syrinx radius and cord tissue compressibility.
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Fluid–structure interactions in a cylindrical layered wave guide with application in the spinal column to syringomyeliaElliott, N.; Lucey, Anthony; Lockerby, D.; Brodbelt, A. (2017)© 2016Syringomyelia is a disease of the spinal cord in which fluid-filled cavities, called syrinxes, form and expand, compressing the surrounding neural tissue and producing neurological damage. This condition can occur ...
Elliott, Novak; Lucey, Anthony; Lockerby, D.; Brodbelt, A. (2010)Syringomyelia is a disease in which fluid-filled cavities, called syrinxes, form in the spinal cord (SC). The progressive expansion of syrinxes over many years compresses the surrounding nerve fibres and blood vessels, ...
Elliott, Novak (2012)Syrinxes are fluid-filled cavities of the spinal cord that characterize syringomyelia, a disease involving neurological damage. Their formation and expansion is poorly understood, which has hindered successful treatment. ...