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    Interferon-? and IL-5 production correlate directly in HIV patients Co-infected with mycobacterium tuberculosis with or without immune restoration disease

    Access Status
    Fulltext not available
    Authors
    Oliver, B.
    Elliott, J.
    Saphonn, V.
    Vun, M.
    French, M.
    Price, Patricia
    Date
    2010
    Type
    Journal Article
    
    Metadata
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    Citation
    Oliver, B. and Elliott, J. and Saphonn, V. and Vun, M. and French, M. and Price, P. 2010. Interferon-? and IL-5 production correlate directly in HIV patients Co-infected with mycobacterium tuberculosis with or without immune restoration disease. AIDS Research and Human Retroviruses. 26 (12): pp. 1287-1289.
    Source Title
    AIDS Research and Human Retroviruses
    DOI
    10.1089/aid.2010.0004
    ISSN
    0889-2229
    School
    School of Biomedical Sciences
    URI
    http://hdl.handle.net/20.500.11937/3963
    Collection
    • Curtin Research Publications
    Abstract

    IL-5 and interferon-? responses were investigated in mitogen-stimulated whole-blood cultures from HIV patients with and without Mycobacterium tuberculosis disease, to determine whether an imbalance of Th1/Th2 cytokines contributes to susceptibility to M. tuberculosis disease or to immune restoration disease (IRD) associated with M. tuberculosis after starting antiretroviral therapy (ART). Interferon-? levels were constant on ART, whilst IL-5 levels generally rose over time. We suggest that increased IL-5 production reflects a recovery of CD4 + T cell function and that a Th1/Th2 imbalance is not associated with increased susceptibility to M. tuberculosis disease or IRD associated with M. tuberculosis upon starting ART. Copyright © 2010, Mary Ann Liebert, Inc.

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