Interferon-? and IL-5 production correlate directly in HIV patients Co-infected with mycobacterium tuberculosis with or without immune restoration disease
MetadataShow full item record
IL-5 and interferon-? responses were investigated in mitogen-stimulated whole-blood cultures from HIV patients with and without Mycobacterium tuberculosis disease, to determine whether an imbalance of Th1/Th2 cytokines contributes to susceptibility to M. tuberculosis disease or to immune restoration disease (IRD) associated with M. tuberculosis after starting antiretroviral therapy (ART). Interferon-? levels were constant on ART, whilst IL-5 levels generally rose over time. We suggest that increased IL-5 production reflects a recovery of CD4 + T cell function and that a Th1/Th2 imbalance is not associated with increased susceptibility to M. tuberculosis disease or IRD associated with M. tuberculosis upon starting ART. Copyright © 2010, Mary Ann Liebert, Inc.
Showing items related by title, author, creator and subject.
Mycobacterial antibody levels and immune restoration disease in HIV patients treated in South East AsiaSumatoh, H.; Oliver, B.; Kumar, M.; Elliott, J.; Vonthanak, S.; Vun, M.; Singh, S.; Agarwal, U.; Kumar, A.; Tan, H.; Kamarulzaman, A.; Yunihastuti, E.; Saraswati, H.; Price, Patricia (2011)Aim: Immune restoration disease (IRD) associated with Mycobacterium tuberculosis parallels the reconstitution of a pathogen-specific Th1 response. However, it is not clear whether humoral responses to M. tuberculosis ...
Lun, S.; Guo, H.; Onajole, O.; Pieroni, M.; Gunosewoyo, Hendra; Chen, G.; Tipparaju, S.; Ammerman, N.; Kozikowski, A.; Bishai, W. (2013)Responsible for nearly two million deaths each year, the infectious disease tuberculosis remains a serious global health challenge. The emergence of multidrug- and extensively drug-resistant strains of Mycobacterium ...
Global, regional, and national incidence and mortality for HIV, tuberculosis, and malaria during 1990–2013: a systematic analysis for the Global Burden of Disease Study 2013Murray, C.; Miller, Ted (2014)Background - The Millennium Declaration in 2000 brought special global attention to HIV, tuberculosis, and malaria through the formulation of Millennium Development Goal (MDG) 6. The Global Burden of Disease 2013 study ...