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    Can immunogenetics illuminate the diverse manifestations of respiratory infections?

    Access Status
    Fulltext not available
    Authors
    Affandi, J.
    Price, Patricia
    Waterer, G.
    Date
    2010
    Type
    Journal Article
    
    Metadata
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    Citation
    Affandi, J. and Price, P. and Waterer, G. 2010. Can immunogenetics illuminate the diverse manifestations of respiratory infections?. Therapeutic Advances in Respiratory Disease. 4 (3): pp. 161-176.
    Source Title
    Therapeutic Advances in Respiratory Disease
    DOI
    10.1177/1753465810371484
    ISSN
    1753-4658
    School
    School of Biomedical Sciences
    URI
    http://hdl.handle.net/20.500.11937/39758
    Collection
    • Curtin Research Publications
    Abstract

    Improved technologies for high-throughput genotyping and the establishment of well-defined cohorts prompted hope that polymorphisms would be discovered that define a patients' risk of respiratory disease or aid in diagnosis. Genetic pitfalls encountered in this quest include genotyping errors, ethnic differences and linkage dysequilibrium. Differences in the definition of the disease phenotype also create discrepancies, so immunogenetic testing has not yet reached the clinic. However, associations between a polymorphism and a disease phenotype place the gene or one in linkage dysequilibrium on the path to the disease. Here we review studies of immune-related genes that are illuminating the immunopathogenesis of community-acquired pneumonia and mycobacterial infections. © 2010 The Author(s).

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