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dc.contributor.authorLee, Andy
dc.contributor.authorSu, Tara
dc.contributor.authorPasalich, Maria
dc.contributor.authorTang, Li
dc.contributor.authorBinns, Colin
dc.contributor.authorQiu, Liqian
dc.identifier.citationLee, A. and Su, T. and Pasalich, M. and Tang, L. and Binns, C. and Qiu, L. 2014. Soy and Isoflavone Intake Associated With Reduced Risk of Ovarian Cancer in Southern Chinese Women. Nutrition Research. 34 (4): pp. 302-307.

Isoflavones, mainly found in soy, have been shown to inhibit ovarian cancer cell proliferation. We hypothesized that soy consumption and isoflavone intake are related to the risk of ovarian cancer. A case–control study was conducted in southern China to ascertain this hypothesis. Five hundred incident patients with histologically confirmed cancer of the ovary and 500 controls (mean age 59 years) were recruited from four public hospitals in Guangzhou. Information on habitual consumption of soy foods, including soybean, soy milk, fresh tofu, dried tofu, and soybean sprout, was obtained face-to-face from participants through a validated and reliable semi-quantitative food frequency questionnaire. Isoflavone intakes were then estimated using the USDA nutrient database. The ovarian cancer patients reported lower consumption levels of individual and total soy foods (75.3 ± 53.6 g/day) compared to the controls (110.7 ± 88.8 g/day). Logistic regression analyses showed that regular intake of soy foods could reduce the ovarian cancer risk, the adjusted odds ratio being 0.29 (95% confidence interval 0.20 to 0.42) for women who consumed at least 120 g/day relative to those less than 61 g/day. Similarly, isoflavone intakes were inversely associated with the ovarian cancer risk, with significant dose–response relationships (P < 0.001). We concluded that consumption of soy foods is associated with a reduced risk of ovarian cancer in southern Chinese women.

dc.publisherElsevier Inc.
dc.subjectCase–control study
dc.subjectSoy foods
dc.titleSoy and Isoflavone Intake Associated With Reduced Risk of Ovarian Cancer in Southern Chinese Women
dc.typeJournal Article
dcterms.source.titleNutrition Research

NOTICE: This is the author’s version of a work that was accepted for publication in Nutrition Research. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Nutrition Research, Vol. 34, Issue 4, (2014).

curtin.departmentSchool of Public Health
curtin.accessStatusOpen access

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