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    The Influence of Temperature and Drug Concentrations Prednisolone in NIPAAm Copolymer

    217892_76122_Pub_72876.pdf (2.597Mb)
    Access Status
    Open access
    Authors
    Setiyorini, Y.
    Lou, Xia
    Pintowantoro, S.
    Date
    2012
    Type
    Journal Article
    
    Metadata
    Show full item record
    Citation
    Setiyorini, Y. and Lou, X. and Pintowantoro, S. 2012. The Influence of Temperature and Drug Concentrations Prednisolone in NIPAAm Copolymer. Procedia Chemistry. 4: pp. 336-342.
    Source Title
    Procedia Chemistry
    DOI
    10.1016/j.proche.2012.06.047
    ISSN
    1876-6196
    School
    Department of Chemical Engineering
    Remarks

    This open access article is distributed under the Creative Commons license http://creativecommons.org/licenses/by-nc-nd/3.0/

    URI
    http://hdl.handle.net/20.500.11937/39910
    Collection
    • Curtin Research Publications
    Abstract

    Controlled delivery systems would be more beneficial and ideal if the drug could be delivered with respond to external environmental change. It could be used to overcome the shortcomings of conventional dosage forms. Therefore, the correct amount of drug would be released upon the stimulation of such a temperature and concentration change. The purpose of study is to investigate the influence of temperature and drug concentration from poly(2-hydroxyethyl methacrylate and N-isopropylacrylamide)/poly(HEMA-NIPAAm). The macroporous structure 5HEMA15NIPAAm was showed the most rapid responsiveness in swelling ratio, polymer volume fraction, swelling and deswelling kinetics. The high drug loading capacity was achieved at or below ambient temperature, whilst the release profile was revealed sustain release of conventional anti-inflammatory drug; prednisolone 21 hemisuccinate sodium salt. In general, drug loading capacity and drug diffusion kinetics are influence by the porosity of hydrogels, temperature, and drug concentration.

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