Longitudinal Modelling of Body Mass Index from Birth to 14 Years
MetadataShow full item record
Background: To examine the tracking of BMI from birth to age 14 years. Participants and Methods: Linear mixed model (LMM) analysis was used to model the trajectories of BMI (n = 1,403). Adiposity rebound was investigated for a subset of individuals (n = 173). Results: Adolescents who were overweight or obese at 14 years followed a different BMI trajectory from birth compared to those of normal weight. There was a difference between weight status groups for the timing of adiposity rebound (p <0.001) and BMI at nadir (p <0.001). The LMM depicted a significant difference in rate of change of BMI over time for males and females (p <0.001), with female BMI increasing at a faster rate, andfor weight status groups (p <0.005), with the obese cohort having the faster increase in BMI over time. BMI at birth was significantly lower for the normal weight cohort compared to the overweight (p = 0.029) and obese (p = 0.019) cohorts. Conclusion: This study introduces apowerful analytic tool, LMM, to model BMI and shows that weight status at 14 years is the result of a distinct path in earlier years. Compared to their normal weight peers, overweight and obese adolescents experience an earlier adiposity rebound, with a higher BMI at rebound.
Showing items related by title, author, creator and subject.
Differential SLC6A4 methylation: a predictive epigenetic marker of adiposity from birth to adulthoodLillycrop, K.; Garratt, E.; Titcombe, P.; Melton, Phillip; Murray, R.; Barton, S.; Clarke-Harris, R.; Costello, P.; Holbrook, J.; Hopkins, J.; Childs, C.; Paras-Chavez, C.; Calder, P.; Mori, T.; Beilin, L.; Burdge, G.; Gluckman, P.; Inskip, H.; Harvey, N.; Hanson, M.; Huang, R.; Cooper, C.; Godfrey, K. (2019)© 2019, The Author(s). Background: The early life environment may influence susceptibility to obesity and metabolic disease in later life through epigenetic processes. SLC6A4 is an important mediator of serotonin ...
Ayonrinde, Oyekoya; Olynyk, John; Marsh, J.; Beilin, L.; Mori, T.; Oddy, W.; Adams, L. (2015)Background and Aim: Nonalcoholic fatty liver disease (NAFLD) and its metabolic risk factors are recognized during childhood and adolescence. Identification of adolescents at risk of NAFLD from childhood anthropometry may ...
Peters, S.; Huxley, Rachel; Woodward, M. (2015)Objective: To conduct a comprehensive examination of the association between women’s reproductive health factors and measures of body adiposity in a contemporary Western population. Methods: A cross-sectional analysis of ...