Airway epithelial repair in health and disease: Orchestrator or simply a player?
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Epithelial cells represent the most important surface of contact in the body and form the first line of defence of the body to external environment. Consequently, epithelia have numerous roles in order to maintain a homeostatic defence barrier. Although the epithelium has been extensively studied over several decades, it remains the focus of new research, indicating a lack of understanding that continues to exist around these cells in specific disease settings. Importantly, evidence is emerging that airway epithelial cells in particular have varied complex functions rather than simple passive roles. One area of current interest is its role following injury. In particular, the epithelial-specific cellular mechanisms regulating their migration during wound repair remain poorly understood and remain an area that requires much needed investigation. A better understanding of the physiological, cellular and molecular wound repair mechanisms could assist in elucidating pathological processes that contribute to airway epithelial pathology. This review attempts to highlight migration-specific and cell-extracellular matrix (ECM) aspects of repair used by epithelial cells under normal and disease settings, in the context of human airways.
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Kicic, Anthony; Stevens, P.; Sutanto, E.; Kicic-Starcevich, E.; Ling, K.; Looi, K.; Martinovich, K.; Garratt, L.; Iosifidis, T.; Shaw, N.; Buckley, A.; Rigby, P.; Lannigan, F.; Knight, D.; Stick, S. (2016)© 2016 John Wiley & Sons Ltd Background: The airway epithelium forms an effective immune and physical barrier that is essential for protecting the lung from potentially harmful inhaled stimuli including viruses. Human ...
Reduced transforming growth factor ß1 (TGF-ß1) in the repair of airway epithelial cells of children with asthmaLing, K.; Sutanto, E.; Iosifidis, T.; Kicic-Starcevich, E.; Looi, K.; Garratt, L.; Martinovich, K.; Lannigan, F.; Knight, D.; Stick, S.; Kicic, Anthony (2016)© 2016 Asian Pacific Society of Respirology Background and objective: Evidence into the role of TGF-ß1 in airway epithelial repair in asthma is still controversial. This study tested the hypothesis that the reduced TGF-ß1 ...
Transcription factor p63 regulates key genes and wound repair in human airway epithelial Basal cellsWarner, S.; Hackett, T.; Shaheen, F.; Hallstrand, T.; Kicic, Anthony; Stick, S.; Knight, D. (2013)The airway epithelium in asthma displays altered repair and incomplete barrier formation. Basal cells are the progenitor cells of the airway epithelium, and can repopulate other cell types after injury. We previously ...