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    Airway epithelial repair in health and disease: Orchestrator or simply a player?

    Access Status
    Open access via publisher
    Authors
    Iosifidis, T.
    Garratt, L.
    Coombe, Deidre
    Knight, D.
    Stick, S.
    Kicic, A.
    Date
    2016
    Type
    Journal Article
    
    Metadata
    Show full item record
    Citation
    Iosifidis, T. and Garratt, L. and Coombe, D. and Knight, D. and Stick, S. and Kicic, A. 2016. Airway epithelial repair in health and disease: Orchestrator or simply a player? Respirology. 21 (3): pp. 439-448.
    Source Title
    Respirology
    DOI
    10.1111/resp.12731
    ISSN
    1323-7799
    School
    School of Biomedical Sciences
    URI
    http://hdl.handle.net/20.500.11937/4016
    Collection
    • Curtin Research Publications
    Abstract

    Epithelial cells represent the most important surface of contact in the body and form the first line of defence of the body to external environment. Consequently, epithelia have numerous roles in order to maintain a homeostatic defence barrier. Although the epithelium has been extensively studied over several decades, it remains the focus of new research, indicating a lack of understanding that continues to exist around these cells in specific disease settings. Importantly, evidence is emerging that airway epithelial cells in particular have varied complex functions rather than simple passive roles. One area of current interest is its role following injury. In particular, the epithelial-specific cellular mechanisms regulating their migration during wound repair remain poorly understood and remain an area that requires much needed investigation. A better understanding of the physiological, cellular and molecular wound repair mechanisms could assist in elucidating pathological processes that contribute to airway epithelial pathology. This review attempts to highlight migration-specific and cell-extracellular matrix (ECM) aspects of repair used by epithelial cells under normal and disease settings, in the context of human airways.

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