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    Utilisation of primary and secondary G-CSF prophylaxis enables maintenance of optimal dose delivery of standard adjuvant chemotherapy for early breast cancer: An analysis of 1655 patients

    Access Status
    Fulltext not available
    Authors
    Chan, Arlene
    McGregor, S.
    Liang, Wenbin
    Date
    2014
    Type
    Journal Article
    
    Metadata
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    Citation
    Chan, A. and McGregor, S. and Liang, W. 2014. Utilisation of primary and secondary G-CSF prophylaxis enables maintenance of optimal dose delivery of standard adjuvant chemotherapy for early breast cancer: An analysis of 1655 patients. The Breast. 23 (5): pp. 676-682.
    Source Title
    The Breast
    DOI
    10.1016/j.breast.2014.07.004
    ISSN
    09609776
    School
    National Drug Research Institute (NDRI)
    URI
    http://hdl.handle.net/20.500.11937/40229
    Collection
    • Curtin Research Publications
    Abstract

    Optimal outcome for early breast cancer patients receiving adjuvant chemotherapy requires adequate dose delivery, commonly defined as >85% of planned dose of chemotherapy agents. Outside the clinical trial setting, reports from community oncology centres have demonstrated that a significant proportion of patients fail to receive this dose intensity, with neutropenia being the most commonly cited reason for sub-optimal treatment. Data collected prospectively on 1655 patient treated in a single breast cancer centre demonstrates that patients at risk of sub-optimal dose delivery can be identified by routine assessment of neutropenic events during the first cycle. The uniform administration of secondary G-CSF for all subsequent cycles enables dose delivery ≥85%, which was shown to lead to improved survival outcomes when compared with those patients who received <85%.

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