Show simple item record

dc.contributor.authorFritschi, Lin
dc.contributor.authorBenke, G.
dc.contributor.authorRisch, H.
dc.contributor.authorSchulte, A.
dc.contributor.authorWebb, P.
dc.contributor.authorWhiteman, D.
dc.contributor.authorFawcett, J.
dc.contributor.authorNeale, R.
dc.date.accessioned2017-01-30T14:43:21Z
dc.date.available2017-01-30T14:43:21Z
dc.date.created2015-12-10T04:25:55Z
dc.date.issued2015
dc.identifier.citationFritschi, L. and Benke, G. and Risch, H. and Schulte, A. and Webb, P. and Whiteman, D. and Fawcett, J. et al. 2015. Occupational exposure to N-nitrosamines and pesticides and risk of pancreatic cancer. Occupational and Environmental Medicine. 72: pp. 678-683.
dc.identifier.urihttp://hdl.handle.net/20.500.11937/40480
dc.identifier.doi10.1136/oemed-2014-102522
dc.description.abstract

Objectives Animal evidence shows that N-nitrosamines and similar xenobiotic compounds are pancreatic carcinogens. We aimed to determine whether occupational exposure to N-nitrosamines or to pesticides increases risk of pancreatic cancer development. Methods Participants (504 cases, 643 controls) in a population-based case-control study (The Queensland Pancreatic Cancer Study) provided data on demographic, medical and lifestyle factors and lifetime job histories. Specific questions were asked regarding work in rubber and leather industries, metalworking jobs and occupational or direct use of pesticides on animals or crops. An occupational hygienist reviewed this information (blind to case status) to assess likelihood of exposure to N-nitrosamines and pesticides, and estimated level and frequency of such exposures. Results No associations were found for risk of pancreatic cancer and occupational exposure to N-nitrosamines (OR=0.85, 95% CI 0.51 to 1.42) and no associations were seen with level or frequency of exposure. No associations were observed for ever exposure to pesticides in general (OR=0.90, 95% CI 0.61 to 1.33) or to any of the pesticide subgroups. Stratification by history of cigarette smoking did not change these results. Conclusions This comprehensive analysis of a large case-control study does not support an association between occupational exposure to N-nitrosamines or pesticide use and risk of pancreatic cancer.

dc.publisherBMJ Publishing Group
dc.titleOccupational exposure to N-nitrosamines and pesticides and risk of pancreatic cancer
dc.typeJournal Article
dcterms.source.volume72
dcterms.source.startPage678
dcterms.source.endPage683
dcterms.source.issn1351-0711
dcterms.source.titleOccupational and Environmental Medicine
curtin.note

This article has been accepted for publication in Occupational and Environmental Medicine following peer review. The definitive copyedited, typeset version: Fritschi, L. and Benke, G. and Risch, H. and Schulte, A. and Webb, P. and Whiteman, D. and Fawcett, J. et al. 2015. Occupational exposure to N-nitrosamines and pesticides and risk of pancreatic cancer. Occupational and Environmental Medicine. 72: pp. 678-683 is available at http://oem.bmj.com/

curtin.departmentEpidemiology and Biostatistics
curtin.accessStatusOpen access


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record