Is potroom asthma due more to sulphur dioxide than fluoride? An inception cohort study in the Australian aluminium industry
MetadataShow full item record
Methods: An inception cohort study was conducted at two Australian aluminium smelters where 446 employees participated over a period of 9 years. Cumulative exposures between interviews were estimated from job histories using a task exposure matrix based on measurements in the smelters. Participants completed an MRC respiratory questionnaire, spirometry and methacholine challenge test. Data were analysed with generalised estimating equations to allow for repeated measurements of each participant. Results: Wheeze and chest tightness, the two symptoms most closely related to asthma, showed associations with occupational exposures. SO2 exposure was significantly associated with these symptoms, bronchial hyper-responsiveness (BHR) to methacholine (a feature of asthma), airflow limitation (reduced forced expiratory volume in 1 second/forced vital capacity ratio) and longitudinal decline in lung function. Fluoride exposure was associated with the same outcomes, but less strongly. Inhalable dust and the benzene soluble fraction (BSF) were associated with symptoms of asthma and BHR. Although many of the exposures were highly correlated, further modelling suggested that of the known respiratory irritants, SO2 was more likely than fluoride to be primarily responsible for the symptoms observed. Fluoride, inhalable dust and SO2 were the most important airborne contaminants associated with effects on lung function. Conclusions: The observed effects were detected at contaminant levels within occupational exposure standards, so further reductions are required, particularly in SO2 exposures.
Showing items related by title, author, creator and subject.
Rumchev, Krassi (2001)Asthma is a common chronic disorder in Western countries and is increasing in prevalence in both children and adults. Although genetic risk for atopy is an important factor for the development of asthma, it does not explain ...
Antioxidant and omega-3 fatty acid intake in the modulation of respiratory illness & asthma in childrenNikravan, Ramin (2011)Background and aim: Asthma is one of the major public health problems in Australia with prevalence in West Australian children reported up to 31%. The rise in asthma prevalence in Western societies may be related to changes ...
The impact of domestic and school air quality on respiratory symptoms among primary school students with different socioeconomic backgroundsMostafaee, Masoud (2010)Respiratory symptoms including wheezing, tight chest, breathing difficulty, are common childhood disorders, and are the most important reasons for (National Health and Medical Research Council 1996; Rumchev, Spickett et ...