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    New anti-tuberculosis drugs in clinical trials with novel mechanisms of action

    Access Status
    Fulltext not available
    Authors
    Rivers, E.
    Mancera, Ricardo
    Date
    2008
    Type
    Journal Article
    
    Metadata
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    Citation
    Rivers, Emma and Mancera, Ricardo. 2008. New anti-tuberculosis drugs in clinical trials with novel mechanisms of action. Drug Discovery Today. 13 (23-24): pp. 1090-1098.
    Source Title
    Drug Discovery Today
    DOI
    10.1016/j.drudis.2008.09.004
    ISSN
    13596446
    Faculty
    Faculty of Health Sciences
    School of Biomedical Sciences
    Remarks

    The link to the journal’s home page is: http://www.elsevier.com/wps/find/journaldescription.cws_home/30921/description#description

    Copyright © 2008 Elsevier B.V. All rights reserved.

    URI
    http://hdl.handle.net/20.500.11937/41035
    Collection
    • Curtin Research Publications
    Abstract

    Tuberculosis is a major health problem worldwide, with approximately 1.7 million people dying annually from the disease. The long current drug regimen, the emergence of drug resistant strains and HIV co-infection have resulted in a resurgence in research efforts to address the urgent need for new anti-tuberculosis drugs. A number of new potential anti-tuberculosis drug candidates with novel modes of action have entered clinical trials in recent years. These agents are most likely to be effective against resistant strains. We provide a concise review of their structure-activity relationships, in vitro and in vivo activity, pharmacokinetics, mechanism of action and combination regimens.

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