New anti-tuberculosis drugs in clinical trials with novel mechanisms of action
Access Status
Authors
Date
2008Type
Metadata
Show full item recordCitation
Source Title
ISSN
Faculty
Remarks
The link to the journal’s home page is: http://www.elsevier.com/wps/find/journaldescription.cws_home/30921/description#description
Copyright © 2008 Elsevier B.V. All rights reserved.
Collection
Abstract
Tuberculosis is a major health problem worldwide, with approximately 1.7 million people dying annually from the disease. The long current drug regimen, the emergence of drug resistant strains and HIV co-infection have resulted in a resurgence in research efforts to address the urgent need for new anti-tuberculosis drugs. A number of new potential anti-tuberculosis drug candidates with novel modes of action have entered clinical trials in recent years. These agents are most likely to be effective against resistant strains. We provide a concise review of their structure-activity relationships, in vitro and in vivo activity, pharmacokinetics, mechanism of action and combination regimens.
Related items
Showing items related by title, author, creator and subject.
-
Lun, S.; Guo, H.; Onajole, O.; Pieroni, M.; Gunosewoyo, Hendra; Chen, G.; Tipparaju, S.; Ammerman, N.; Kozikowski, A.; Bishai, W. (2013)Responsible for nearly two million deaths each year, the infectious disease tuberculosis remains a serious global health challenge. The emergence of multidrug- and extensively drug-resistant strains of Mycobacterium ...
-
Lun, S.; Xiao, S.; Zhang, W.; Wang, S.; Gunosewoyo, Hendra ; Yu, L.F.; Bishai, W.R. (2021)Polyketide synthase 13 (Pks13) is an important enzyme found in Mycobacterium tuberculosis that condenses two fatty acyl chains to produce a-alkyl b-ketoesters, which in turn serve as the precursors for the synthesis of ...
-
Murray, C.; Miller, Ted (2014)Background - The Millennium Declaration in 2000 brought special global attention to HIV, tuberculosis, and malaria through the formulation of Millennium Development Goal (MDG) 6. The Global Burden of Disease 2013 study ...