Implications of Exercise-Induced Pulmonary Arterial Hypertension
dc.contributor.author | Fowler, R. | |
dc.contributor.author | Maiorana, Andrew | |
dc.contributor.author | Jenkins, Susan | |
dc.contributor.author | Gain, Kevin | |
dc.contributor.author | O'Driscoll, G. | |
dc.contributor.author | Gabbay, E. | |
dc.date.accessioned | 2017-01-30T14:47:57Z | |
dc.date.available | 2017-01-30T14:47:57Z | |
dc.date.created | 2012-03-27T20:01:11Z | |
dc.date.issued | 2011 | |
dc.identifier.citation | Fowler, Robin M. and Maiorana, Andrew J. and Jenkins, Sue C. and Gain, Kevin R. and O'Driscoll, Gerry and Gabbay, Eli. 2011. Implications of Exercise-Induced Pulmonary Arterial Hypertension. Medicine & Science in Sports & Exercise. 43 (6): pp. 983-989. | |
dc.identifier.uri | http://hdl.handle.net/20.500.11937/41052 | |
dc.identifier.doi | 10.1249/MSS.0b013e318204cdac | |
dc.description.abstract |
Purpose: To characterize the hemodynamic and ventilatory responses to exercise in a group of patients with unexplained dyspnea, increased risk for pulmonary arterial hypertension (PAH), and an elevated mean pulmonary artery pressure (mPAP; >30 mm Hg) on exercise. Methods: A total of 37 symptomatic patients at risk of PAH and 20 healthy controls underwent a cardiopulmonary exercise test and were assessed for quality of life (QOL). Patients had a pulmonary artery catheter in situ during the exercise test. Results: Seventeen subjects had exercise-induced PAH (EIPAH), which we defined as mPAP ≤ 25 mm Hg at rest, and mPAP > 30 mm Hg and pulmonary artery wedge pressure <20 mm Hg on exercise. These subjects had reduced peak exercise cardiac output (72% ± 19% predicted). Further, compared with matched controls, subjects with EIPAH had reduced peak oxygen consumption (1.2 ± 0.4 vs 1.7 ± 0.5 L•min−1, P < 0.05), an elevated ventilatory equivalent for carbon dioxide (41.0 ± 7.3 vs 31.0 ± 2.9, P < 0.05) and reduced end-tidal carbon dioxide tension (32.6 ± 3.6 vs 39.4 ± 2.7 mm Hg, P < 0.05) at the anaerobic threshold. These exercise abnormalities were associated with impaired QOL (P < 0.05). Conclusions: Elevated pulmonary artery pressure on exercise can be associated with hemodynamic and ventilatory abnormalities typical of PAH, along with impaired exercise capacity and reduced QOL. | |
dc.publisher | Lippincott Williams & Wilkins | |
dc.title | Implications of Exercise-Induced Pulmonary Arterial Hypertension | |
dc.type | Journal Article | |
dcterms.source.volume | 43 | |
dcterms.source.number | 6 | |
dcterms.source.startPage | 983 | |
dcterms.source.endPage | 989 | |
dcterms.source.issn | 0195-9131 | |
dcterms.source.title | Medicine & Science in Sports & Exercise | |
curtin.department | School of Physiotherapy | |
curtin.accessStatus | Open access via publisher |