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dc.contributor.authorShanmugam, M.
dc.contributor.authorDai, X.
dc.contributor.authorKumar, Alan Prem
dc.contributor.authorTan, B.
dc.contributor.authorSethi, G.
dc.contributor.authorBishayee, A.
dc.date.accessioned2017-01-30T14:49:56Z
dc.date.available2017-01-30T14:49:56Z
dc.date.created2014-01-07T20:00:48Z
dc.date.issued2013
dc.identifier.citationShanmugam, Muthu K. and Dai, Xiaoyan and Kumar, Alan Prem and Tan, Benny K.H. and Sethi, Gautam and Bishayee, Anupam. 2013. Ursolic acid in cancer prevention and treatment: Molecular targets, pharmacokinetics and clinical studies. Biochemical Pharmacology. 85 (11): pp. 1579-1587.
dc.identifier.urihttp://hdl.handle.net/20.500.11937/41259
dc.identifier.doi10.1016/j.bcp.2013.03.006
dc.description.abstract

Discovery of bioactive molecules and elucidation of their molecular mechanisms open up an enormous opportunity for the development of improved therapy for different inflammatory diseases, including cancer. Triterpenoids isolated several decades ago from various medicinal plants now seem to have a prominent role in the prevention and therapy of a variety of ailments and some have already entered Phase I clinical trials. One such important and highly investigated pentacyclic triterpenoid, ursolic acid has attracted great attention of late for its potential as a chemo preventive and chemotherapeutic agent in various types of cancer. Ursolic acid has been shown to target multiple pro inflammatory transcription factors, cell cycle proteins, growth factors, kinases, cytokines, chemokines, adhesion molecules, and inflammatory enzymes. These targets can potentially mediate the chemo preventive and therapeutic effects of ursolic acid by inhibiting the initiation, promotion and metastasis of cancer. This review not only summarizes the diverse molecular targets of ursolic acid, but also provides an insight into the various preclinical and clinical studies that have been performed in the last decade with this promising triterpenoid.

dc.publisherElsevier
dc.subjectUrsolic acid
dc.subjectApoptosis
dc.subjectNF-kB
dc.subjectChemoprevention
dc.subjectSTAT3
dc.subjectCancer
dc.titleUrsolic acid in cancer prevention and treatment: Molecular targets, pharmacokinetics and clinical studies
dc.typeJournal Article
dcterms.source.volume85
dcterms.source.startPage1579
dcterms.source.endPage1587
dcterms.source.issn0006-2952
dcterms.source.titleBiochemical Pharmacology
curtin.department
curtin.accessStatusFulltext not available


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