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    Individual differences in substance dependence: At the intersection of brain, behaviour and cognition

    Access Status
    Fulltext not available
    Authors
    Baker, T.
    Stockwell, Tim
    Barnes, G.
    Holroyd, C.
    Date
    2011
    Type
    Journal Article
    
    Metadata
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    Citation
    Baker, T. and Stockwell, T. and Barnes, G. and Holroyd, C. 2011. Individual differences in substance dependence: At the intersection of brain, behaviour and cognition. Addiction Biology. 16 (3): pp. 458-466.
    Source Title
    Addiction Biology
    DOI
    10.1111/j.1369-1600.2010.00243.x
    ISSN
    1355-6215
    School
    National Drug Research Institute (NDRI)
    URI
    http://hdl.handle.net/20.500.11937/41286
    Collection
    • Curtin Research Publications
    Abstract

    Recent theories of drug dependence propose that the transition from occasional recreational substance use to harmful use and dependence results from the impact of disrupted midbrain dopamine signals for reinforcement learning on frontal brain areas that implement cognitive control and decision-making. We investigated this hypothesis in humans using electrophysiological and behavioral measures believed to assay the integrity of midbrain dopamine system and its neural targets. Our investigation revealed two groups of dependent individuals, one characterized by disrupted dopamine-dependent reward learning and the other by disrupted error learning associated with depression-proneness. These results highlight important neurobiological and behavioral differences between two classes of dependent users that can inform the development of individually tailored treatment programs.

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