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dc.contributor.authorAffandi, J.
dc.contributor.authorKumar, M.
dc.contributor.authorAgarwal, U.
dc.contributor.authorSingh, S.
dc.contributor.authorPrice, Patricia
dc.identifier.citationAffandi, J. and Kumar, M. and Agarwal, U. and Singh, S. and Price, P. 2013. The search for a genetic factor associating with immune restoration disease in HIV patients co-infected with Mycobacterium tuberculosis. Disease Markers. 34 (6): pp. 445-449.

BACKGROUND: Up to 43% of HIV-infected patients co-infected with Mycobacterium tuberculosis experience exacerbations of tuberculosis (TB) after commencing antiretroviral therapy (ART). These are termed immune restoration disease (IRD). It is unclear why individual susceptibility varies. OBJECTIVE: We investigate if single nucleotide polymorphisms (SNP) in genes encoding cytokines, chemokines and their receptors associate with development of an IRD event in patients of two different ethnicities. METHODS: DNA samples were available from small well-characterised groups of HIV patients treated in Cambodia (TB-IRD, n=17; HIV^{+}TB^{+} controls, n=55) and India (TB-IRD, n=19; HIV^{+}TB^{+} controls, n= 43). HIV patients with a TB diagnosis but no evidence of IRD were included to control for susceptibility to TB per se. Sixteen SNP implicated in inflammation or mycobacterial disease were genotyped. RESULTS: Susceptibility to TB-IRD associated with carriage of TNFA-1031*T (rs1799964; P=0.05) and SLC11A1 D543N*G (rs17235409; P=0.04) in Cambodian patients and carriage of IL18-607*G (rs1946518; P=0.02) and VDR FokI (F/f)*T (rs10735810; P=0.05) in Indian patients. CONCLUSIONS: Associations between polymorphisms in immune-related genes and TB-IRD were found, but none were common across two ethnicities. © 2013 - IOS Press and the authors. All rights reserved.

dc.titleThe search for a genetic factor associating with immune restoration disease in HIV patients co-infected with Mycobacterium tuberculosis
dc.typeJournal Article
dcterms.source.titleDisease Markers
curtin.departmentSchool of Biomedical Sciences
curtin.accessStatusFulltext not available

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