Saturated and unsaturated (including arachidonic acid) non-esterified fatty acid modulation of insulin secretion from pancreatic ß-cells
MetadataShow full item record
Both stimulatory and detrimental effects of NEFAS (non-esterified fatty acids) on pancreatic ß-cells have been recognized. Acute exposure of the pancreatic ß-cell to high glucose concentrations and/or saturated NEFAs results in a substantial increase in insulin release, whereas chronic exposure results in desensitization and suppression of secretion followed by induction of apoptosis. Some unsaturated NEFAs also promote insulin release acutely, but they are less toxic to ß-cells during chronic exposure and can even exert positive protective effects. In the present review, we focus on exogenous and endogenous effects of NEFAs, including the polyunsaturated fatty acid, arachidonic acid (or its metabolites generated from cyclo-oxygenase activity), on ß-cell metabolism, and have explored the outcomes with respect to ß-cell insulin secretion. © The Authors Journal Compilation. © 2008 Biochemical Society.
Showing items related by title, author, creator and subject.
Elevated levels of branched-chain amino acids have little effect on pancreatic islet cells, but L-arginine impairs function through activation of the endoplasmic reticulum stress responseMullooly, N.; Vernon, W.; Smith, D.; Newsholme, Philip (2014)New Findings - What is the central question of this study?: Recent studies have demonstrated strong correlations between circulating branched-chain amino acid (AA) levels and insulin resistance, a predictor of susceptibility ...
Newsholme, Philip; Cruzat, Vinicius; Arfuso, Frank; Keane, Kevin (2014)Pancreatic ß-cell function is of critical importance in the regulation of fuel homoeostasis, and metabolic dysregulation is a hallmark of diabetes mellitus (DM). The ß-cell is an intricately designed cell type that couples ...
Newsholme, Philip; Krause, M. (2012)Pancreatic ß-cells are exquisitely organised to continually monitor and respond to dietary nutrients, under the modulation of additional neurohormonal signals, in order to secrete insulin to best meet the needs of the ...