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    Saturated and unsaturated (including arachidonic acid) non-esterified fatty acid modulation of insulin secretion from pancreatic ß-cells

    Access Status
    Open access via publisher
    Authors
    Keane, D.
    Newsholme, Philip
    Date
    2008
    Type
    Journal Article
    
    Metadata
    Show full item record
    Citation
    Keane, D. and Newsholme, P. 2008. Saturated and unsaturated (including arachidonic acid) non-esterified fatty acid modulation of insulin secretion from pancreatic ß-cells. Biochemical Society. Transactions. 36 (5): pp. 955-958.
    Source Title
    Biochemical Society. Transactions
    DOI
    10.1042/BST0360955
    ISSN
    0300-5127
    School
    School of Biomedical Sciences
    URI
    http://hdl.handle.net/20.500.11937/41620
    Collection
    • Curtin Research Publications
    Abstract

    Both stimulatory and detrimental effects of NEFAS (non-esterified fatty acids) on pancreatic ß-cells have been recognized. Acute exposure of the pancreatic ß-cell to high glucose concentrations and/or saturated NEFAs results in a substantial increase in insulin release, whereas chronic exposure results in desensitization and suppression of secretion followed by induction of apoptosis. Some unsaturated NEFAs also promote insulin release acutely, but they are less toxic to ß-cells during chronic exposure and can even exert positive protective effects. In the present review, we focus on exogenous and endogenous effects of NEFAs, including the polyunsaturated fatty acid, arachidonic acid (or its metabolites generated from cyclo-oxygenase activity), on ß-cell metabolism, and have explored the outcomes with respect to ß-cell insulin secretion. © The Authors Journal Compilation. © 2008 Biochemical Society.

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