Show simple item record

dc.contributor.authorAldous, S.
dc.contributor.authorMark Richards, A.
dc.contributor.authorGeorge, P.
dc.contributor.authorCullen, L.
dc.contributor.authorParsonage, W.
dc.contributor.authorFlaws, D.
dc.contributor.authorFlorkowski, C.
dc.contributor.authorTroughton, R.
dc.contributor.authorO'Sullivan, J.
dc.contributor.authorReid, Christopher
dc.contributor.authorBannister, L.
dc.contributor.authorThan, M.
dc.identifier.citationAldous, S. and Mark Richards, A. and George, P. and Cullen, L. and Parsonage, W. and Flaws, D. and Florkowski, C. et al. 2014. Comparison of new point-of-care troponin assay with high sensitivity troponin in diagnosing myocardial infarction. International Journal of Cardiology. 177 (1): pp. 182-186.

Objectives: The aim of this study is to compare a new improved point of care cardiac troponin assay (new POC-cTnI) with 1. its predecessor (old POC-cTnI) and 2. a high sensitivity assay (hs-cTnI) for the diagnosis of acute myocardial infarction (AMI) and for major adverse cardiac events (MACE) by 30 days. Methods: This is a single centre observational study, set in Christchurch Hospital, New Zealand. Patients presenting to the emergency department with non-traumatic chest pain underwent blood sampling at 0 h and 2 h post presentation for analysis with the 3 cTnI assays for the outcome of AMI and for analysis using an accelerated diagnostic protocol (ADP-normal 2 h troponins, normal electrocardiograms and Thrombolysis In Myocardial Infarction (TIMI) score of 0 or ≤ 1) for 30 day MACE. Results: Of 962 patients, 220 (22.9%) had AMI. Old POC-cTnI was least sensitive at 70.0% (65.4–73.9%) by 2 h (p < 0.001). New POC-cTnI, sensitivity 93.6% (89.9–96.2%) had similar sensitivity to hs-cTnI, sensitivity 95.0% (91.5–97.3%) (p = 0.508). There were 231 (24.0%) patients with 30 day MACE. When used as part of the ADP, all assays had 100% (98.0–100%) sensitivity using TIMI = 0. Sensitivities of new POC-cTnI ADP, 98.3% (95.4–99.4%), old POC-cTnI, 96.5% (93.2–98.4%) and hs-cTnI, 98.7% (96.0–99.7%) were similar (p = 0.063–0.375) using TIMI ≤ 1. Conclusions: A new POC-cTnI has improved sensitivity for AMI and MACE compared with its predecessor and comparable sensitivity to a high sensitivity assay. Now that sensitivities of the POC assay are improved, the new assay may be a useful alternative to central laboratory assays when rapid turn-around times are not possible.

dc.publisherElsevier Ireland Ltd
dc.titleComparison of new point-of-care troponin assay with high sensitivity troponin in diagnosing myocardial infarction
dc.typeJournal Article
dcterms.source.titleInternational Journal of Cardiology
curtin.departmentDepartment of Health Policy and Management
curtin.accessStatusFulltext not available

Files in this item


This item appears in the following Collection(s)

Show simple item record