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    Clinical and molecular epidemiology of community-onset invasive Staphylococcus aureus infection in New Zealand children

    Access Status
    Fulltext not available
    Authors
    Williamson, D.
    Ritchie, S.
    Roberts, S.
    Coombs, Geoffrey
    Thomas, M.
    Hannaford, O.
    Baker, M.
    Lennon, D.
    Fraser, J.
    Date
    2014
    Type
    Journal Article
    
    Metadata
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    Citation
    Williamson, D. and Ritchie, S. and Roberts, S. and Coombs, G. and Thomas, M. and Hannaford, O. and Baker, M. et al. 2014. Clinical and molecular epidemiology of community-onset invasive Staphylococcus aureus infection in New Zealand children. Epidemiology and Infection. 142 (8): pp. 1713-1721.
    Source Title
    Epidemiology and Infection
    DOI
    10.1017/S0950268814000053
    ISSN
    0950-2688
    School
    School of Biomedical Sciences
    URI
    http://hdl.handle.net/20.500.11937/42385
    Collection
    • Curtin Research Publications
    Abstract

    Our aim was to describe the epidemiology and incidence of community-onset invasive S. aureus disease in children presenting to our hospital, and to compare the clonal complexes and virulence genes of S. aureus strains causing invasive and non-invasive disease. The virulence gene repertoire of invasive disease isolates was characterized using DNA microarray and compared with the virulence gene repertoire of non-invasive S. aureus isolates. Over the study period, 163 children had an invasive S. aureus infection. There was no difference in the distribution of clonal complexes or in the prevalence of genes encoding virulence factors between invasive and non-invasive isolates. Future research should include a strong focus on identifying the host and environmental factors that, along with organism virulence factors, are contributing to the patterns of invasive S. aureus disease observed in New Zealand.

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