Netrin-1 in the developing enteric nervous system and colorectal cancer
| dc.contributor.author | Ko, S. | |
| dc.contributor.author | Dass, Crispin | |
| dc.contributor.author | Nurgali, K. | |
| dc.date.accessioned | 2017-01-30T14:59:26Z | |
| dc.date.available | 2017-01-30T14:59:26Z | |
| dc.date.created | 2013-03-26T20:00:49Z | |
| dc.date.issued | 2012 | |
| dc.identifier.citation | Ko, Suh Youn and Dass, Crispin R. and Nurgali, Kulmira. 2012. Netrin-1 in the developing enteric nervous system and colorectal cancer. Trends in Molecular Medicine. 18 (9): pp. 544-554. | |
| dc.identifier.uri | http://hdl.handle.net/20.500.11937/42410 | |
| dc.identifier.doi | 10.1016/j.molmed.2012.07.001 | |
| dc.description.abstract |
Netrin-1 is a well-characterised chemoattractant involved in neuronal guidance in the developing enteric nervous system (ENS), but it is also a regulator of tumorigenesis. Two of its well-characterised receptors, deleted in colorectal cancer (DCC) and uncoordinated-5 homolog (UNC-5H), belong to a family of dependence receptors that transmit either pro- or anti-apoptosis signals depending on the availability of ligand, in this case netrin-1. This review summarises these two effects of netrin-1 and highlights the additional research needed information about to allow better utilisation of netrin-1 as a therapeutic target for axonal regeneration in the context of colorectal cancer. | |
| dc.publisher | Elsevier Ltd. | |
| dc.subject | dependence receptors | |
| dc.subject | DCC | |
| dc.subject | UNC-5H | |
| dc.subject | Netrin-1 | |
| dc.subject | enteric nervous system | |
| dc.subject | cell survival | |
| dc.subject | colorectal cancer | |
| dc.subject | neuronal guidance | |
| dc.title | Netrin-1 in the developing enteric nervous system and colorectal cancer | |
| dc.type | Journal Article | |
| dcterms.source.volume | 18 | |
| dcterms.source.number | 9 | |
| dcterms.source.startPage | 544 | |
| dcterms.source.endPage | 554 | |
| dcterms.source.issn | 1357-4310 | |
| dcterms.source.title | Trends in Molecular Medicine | |
| curtin.department | ||
| curtin.accessStatus | Fulltext not available |