Segmentation of the C57BL/6J mouse cerebellum in magnetic resonance images
MetadataShow full item record
The C57BL mouse is the centerpiece of efforts to use gene-targeting technology to understand cerebellar pathology, thus creating a need for a detailed magnetic resonance imaging (MRI) atlas of the cerebellum of this strain. In this study we present a methodology for systematic delineation of the vermal and hemispheric lobules of the C57BL/6J mouse cerebellum in magnetic resonance images. We have successfully delineated 38 cerebellar and cerebellar-related structures. The higher signal-to-noise ratio achieved by group averaging facilitated the identification of anatomical structures. In addition, we have calculated average region volumes and created probabilistic maps for each structure. The segmentation method and the probabilistic maps we have created will provide a foundation for future studies of cerebellar disorders using transgenic mouse models.
Showing items related by title, author, creator and subject.
Fu, Y.; Watson, Charles (2012)The arcuate nucleus is a prominent cell group in the human hindbrain, characterized by its position on the pial surface of the pyramid. It is considered to be a precerebellar nucleus and has been implicated in the pathology ...
Chapman, H.; Eramudugolla, R.; Gavrilescu, M.; Strudwick, M.; Loftus, Andrea; Cunnington, R.; Mattingley, J. (2010)Visuomotor adaptation to a shift in visual input produced by prismatic lenses is an example of dynamicsensory-motor plasticity within the brain. Prism adaptation is readily induced in healthy individuals, andis thought ...
Cerebellar anodal tDCS increases implicit learning when strategic re-aiming is suppressed in sensorimotor adaptationLeow, L.; Marinovic, Welber; Riek, S.; Carroll, T. (2017)Neurophysiological and neuroimaging work suggests that the cerebellum is critically involved in sensorimotor adaptation. Changes in cerebellar function alter behaviour when compensating for sensorimotor perturbations, as ...