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    Segmentation of the C57BL/6J mouse cerebellum in magnetic resonance images

    Access Status
    Fulltext not available
    Authors
    Ullmann, J.
    Keller, M.
    Watson, Charles
    Jenke, A.
    Kurniawan, N.
    Yang, Z.
    Richards, K.
    Paxinos, G.
    Egan, G.
    Petrou, S.
    Bartlett, P.
    Galloway, J.
    Reutens, D.
    Date
    2012
    Type
    Journal Article
    
    Metadata
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    Citation
    Ullmann, J. and Keller, M. and Watson, C. and Jenke, A. and Kurniawan, N. and Yang, Z. and Richards, K. et al. 2012. Segmentation of the C57BL/6J mouse cerebellum in magnetic resonance images. NeuroImage. 62 (3): pp. 1408-1414.
    Source Title
    NeuroImage
    DOI
    10.1016/j.neuroimage.2012.05.061
    ISSN
    1053-8119
    School
    School of Biomedical Sciences
    URI
    http://hdl.handle.net/20.500.11937/42580
    Collection
    • Curtin Research Publications
    Abstract

    The C57BL mouse is the centerpiece of efforts to use gene-targeting technology to understand cerebellar pathology, thus creating a need for a detailed magnetic resonance imaging (MRI) atlas of the cerebellum of this strain. In this study we present a methodology for systematic delineation of the vermal and hemispheric lobules of the C57BL/6J mouse cerebellum in magnetic resonance images. We have successfully delineated 38 cerebellar and cerebellar-related structures. The higher signal-to-noise ratio achieved by group averaging facilitated the identification of anatomical structures. In addition, we have calculated average region volumes and created probabilistic maps for each structure. The segmentation method and the probabilistic maps we have created will provide a foundation for future studies of cerebellar disorders using transgenic mouse models.

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