Thymic tissue is not evident on high-resolution computed tomography and [18F]Fluoro-deoxy-glucose positron emission tomography scans of aviraemic HIV patients with poor recovery of CD4                     + T cells

Tanaskovic, S.; Fernandez, S.; French, M.; Price, R.; Song, S.; Robins, P.; Price, Patricia

doi:10.1097/QAD.0b013e3283474155

Access Status

Open access via publisher

Authors

Tanaskovic, S.

Fernandez, S.

French, M.

Price, R.

Song, S.

Robins, P.

Price, Patricia

Date

2011

Type

Journal Article

Metadata

Show full item record

Citation

Tanaskovic, S. and Fernandez, S. and French, M. and Price, R. and Song, S. and Robins, P. and Price, P. 2011. Thymic tissue is not evident on high-resolution computed tomography and [18F]Fluoro-deoxy-glucose positron emission tomography scans of aviraemic HIV patients with poor recovery of CD4 + T cells. AIDS. 25 (9): pp. 1235-1237.

Source Title

AIDS

DOI

10.1097/QAD.0b013e3283474155

ISSN

0269-9370

School

School of Biomedical Sciences

URI

http://hdl.handle.net/20.500.11937/42628

Collection

Curtin Research Publications

Abstract

Some previously immunodeficient HIV patients responding to antiretroviral therapy display poor recovery of CD4 + T cells. Evaluation of the contribution of thymic function requires sensitive detection and quantitation of metabolically active thymic tissue. We describe patients with low but detectable thymopoiesis assessed as circulating CD4 + naive T cells expressing CD31. High-resolution computed tomography and PET scans found no residual thymic tissue even though metabolic activity was demonstrable by PET in lymph nodes.