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    Cerebral glucose metabolism is associated with verbal not visual performance in community-dwelling older adults

    Access Status
    Fulltext not available
    Authors
    Gardner, S.
    Sohrabi, S.
    Shen, K.
    Rainey-Smith, S.
    Weinborn, M.
    Bates, K.
    Shah, T.
    Foster, J.
    Lenzo, N.
    Salvado, O.
    Laske, C.
    Laws, S.
    Taddei, K.
    Verdile, G.
    Martins, R.
    Date
    2016
    Type
    Journal Article
    
    Metadata
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    Citation
    Gardner, S. and Sohrabi, S. and Shen, K. and Rainey-Smith, S. and Weinborn, M. and Bates, K. and Shah, T. et al. 2016. Cerebral glucose metabolism is associated with verbal not visual performance in community-dwelling older adults. Journal of Alzheimer's Disease. 52 (2): pp. 661-672.
    Source Title
    Journal of Alzheimer's Disease
    DOI
    10.3233/JAD-151084
    ISSN
    1875-8908
    School
    School of Biomedical Sciences
    URI
    http://hdl.handle.net/20.500.11937/42758
    Collection
    • Curtin Research Publications
    Abstract

    Increasing evidence suggests that Alzheimer's disease (AD) sufferers show region-specific reductions in cerebral glucose metabolism, as measured by [18F]-fluoro-2-deoxyglucose positron emission tomography (18F-FDG PET). We investigated preclinical disease stage by cross-sectionally examining the association between global cognition, verbal and visual memory, and 18F-FDG PET standardized uptake value ratio (SUVR) in 43 healthy control individuals, subsequently focusing on differences between subjective memory complainers and non-memory complainers. The 18F-FDG PET regions of interest investigated include the hippocampus, amygdala, posterior cingulate, superior parietal, entorhinal cortices, frontal cortex, temporal cortex, and inferior parietal region. In the cohort as a whole, verbal logical memory immediate recall was positively associated with 18F-FDG PET SUVR in both the left hippocampus and right amygdala. There were no associations observed between global cognition, delayed recall in logical memory, or visual reproduction and 18F-FDG PET SUVR. Following stratification of the cohort into subjective memory complainers and non-complainers, verbal logical memory immediate recall was positively associated with 18F-FDG PET SUVR in the right amygdala in those with subjective memory complaints.There were no significant associations observed in non-memory complainers between 18F-FDG PET SUVR in regions of interest and cognitive performance. We observed subjective memory complaint-specific associations between 18F-FDG PET SUVR and immediate verbal memory performance in our cohort, however found no associations between delayed recall of verbal memory performance or visual memory performance. It is here argued that the neural mechanisms underlying verbal and visual memory performance may in fact differ in their pathways, and the characteristic reduction of 18F-FDG PET SUVR observed in this and previous studies likely reflects the pathophysiological changes in specific brain regions that occur in preclinical AD.

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