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    Chemokine receptor expression on dendritic cells is normal in HIV-infected patients with a stable response to ART, but chemokine levels remain elevated

    Access Status
    Fulltext not available
    Authors
    Lee, S.
    Fernandez, S.
    French, M.
    Price, Patricia
    Date
    2011
    Type
    Journal Article
    
    Metadata
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    Citation
    Lee, S. and Fernandez, S. and French, M. and Price, P. 2011. Chemokine receptor expression on dendritic cells is normal in HIV-infected patients with a stable response to ART, but chemokine levels remain elevated. Journal of Medical Virology. 83 (7): pp. 1128-1133.
    Source Title
    Journal of Medical Virology
    DOI
    10.1002/jmv.22080
    ISSN
    0146-6615
    School
    School of Biomedical Sciences
    URI
    http://hdl.handle.net/20.500.11937/42783
    Collection
    • Curtin Research Publications
    Abstract

    The development of strategies to optimize T-cell responses in previously immunodeficient HIV patients with a stable virological response to ART requires an understanding of the factors that affect responsiveness. Chemokines direct the migration of dendritic cells (DC) to non-lymphoid tissues infected by secondary pathogens and to lymph nodes where they prime T-cells. Quantitation of mRNA is a sensitive technique enabling assessment of chemokine receptors by CD14 + monocytes, myeloid (m)DCs, plasmacytoid (p)DCs, and M-DC8 + cells. MDC8 + cells invariably expressed less CCR2, CCR5, and CXCR4 than the other cells, but expression of CCR2, CCR5, CCR6, CCR7, CXCR3, and CXCR4 was similar in patients and healthy controls. However plasma levels of CXCL10, CCL5, and CCL2 remained higher in patients than controls. Overall, it appears that chemokine directed migration of DC may not limit immune responses in these patients. © 2011 Wiley-Liss, Inc.

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