Statins inhibit in vitro virulence phenotypes of Pseudomonas aeruginosa
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Statins are a family of drugs that lower cholesterol levels by inhibiting 3-hydroxy-3-methylglutaryl-CoA-reductase, a rate-limiting enzyme in the human mevalonate pathway of which cholesterol is the biosynthetic end product.1 Statins also have a range of cholesterol-independent effects, including anti-inflammatory functions and antimicrobial activity. These pleiotropic effects are thought to account for the improved survival observed in statin-treated patients suffering from severe bacterial infections, such as sepsis and pneumonia. In order to identify the mechanism involved in the protective effects of statins against infection, research studies focused on the direct effect of statins on bacteria.
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Kurniawan, Dede Indra (2007)Background. Muscle cramps are one of the adverse affects suffered by hypercholesterolemia patients who are treated with statins. Besides reducing cholesterol levels, statins also reduce coenzyme Q10 (CoQ10) blood levels. ...
Allen, S.; Mamotte, Cyril (2017)Statins are widely used to prevent major cardiovascular events by lowering serum cholesterol. There is evidence that statins have pleiotropic effects-that is, cholesterol-independent effects-that may also confer protection ...
Caparrós-Martín, J.; Lareu, R.; Ramsay, J.; Peplies, J.; Jerry Reen, F.; Headlam, H.; Ward, Natalie; Croft, K.; Newsholme, P.; Hughes, J.; O'Gara, F. (2017)BACKGROUND: Statins are a class of therapeutics used to regulate serum cholesterol and reduce the risk of heart disease. Although statins are highly effective in removing cholesterol from the blood, their consumption has ...