Statins inhibit in vitro virulence phenotypes of Pseudomonas aeruginosa
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Statins are a family of drugs that lower cholesterol levels by inhibiting 3-hydroxy-3-methylglutaryl-CoA-reductase, a rate-limiting enzyme in the human mevalonate pathway of which cholesterol is the biosynthetic end product.1 Statins also have a range of cholesterol-independent effects, including anti-inflammatory functions and antimicrobial activity. These pleiotropic effects are thought to account for the improved survival observed in statin-treated patients suffering from severe bacterial infections, such as sepsis and pneumonia. In order to identify the mechanism involved in the protective effects of statins against infection, research studies focused on the direct effect of statins on bacteria.
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Kurniawan, Dede Indra (2007)Background. Muscle cramps are one of the adverse affects suffered by hypercholesterolemia patients who are treated with statins. Besides reducing cholesterol levels, statins also reduce coenzyme Q10 (CoQ10) blood levels. ...
Pallebage-Gamarallage, Menuka Madhavi Somapala (2012)Alzheimer’s disease (AD) is the most common cause of dementia pathologically characterised by neurovascular inflammation, extracellular proteinaceous deposits enriched in amyloid-β (Aβ) and formation of neurofibrillar ...
Cost-Effectiveness of Optimizing Use of Statins in Australia: Using Outpatient Data From the REACH RegistryAdemi, Z.; Reid, Christopher; Hollingsworth, B.; Stoelwinder, J.; Steg, P.; Bhatt, D.; Vale, M.; Liew, D. (2011)Background: Although few cardiovascular registries report the costs of illness or cost-effectiveness of health interventions, such information is critical to inform the effective and cost-effective management of cardiovascular ...