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    Breaking the DNA-vaccine bottleneck

    Access Status
    Fulltext not available
    Authors
    Danquah, Michael
    Forde, G.
    Date
    2011
    Type
    Journal Article
    
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    Citation
    Danquah, M. and Forde, G. 2011. Breaking the DNA-vaccine bottleneck. The Chemical Engineer (838): pp. 40-41.
    Source Title
    TCE
    ISSN
    0302-0797
    School
    Curtin Sarawak
    URI
    http://hdl.handle.net/20.500.11937/42952
    Collection
    • Curtin Research Publications
    Abstract

    Monash University in Australia has developed a new approach towards DNA vaccine development that has the potential to cut the time it takes to produce a vaccine from up to nine months to four weeks or less. The university has designed and filed a patent on a commercially viable, single-stage technology for manufacturing DNA molecules. The technology was used to produce malaria and measles DNA vaccines, which were tested to be homogeneous supercoiled DNA, free from RNA and protein contaminations and meeting FDA regulatory standards for DNA vaccines. The technique is based on customized, smart, polymeric, monolithic adsorbents that can purify DNA very rapidly. The design criteria of solid-phase adsorbent include rapid adsorption and desorption kinetics, physical composition, and adequate selectivity , capacity and recovery. The new show technology significantly improved binding capacities, higher recovery, drastically reduced use of buffers and processing time, less clogging, and higher yields of DNA.

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