Structural biology of antibody recognition of carbohydrate epitopes and potential uses for targeted cancer immunotherapies
MetadataShow full item record
Monoclonal antibodies represent the most successful class of biopharmaceuticals for the treatment of cancer. Mechanisms of action of therapeutic antibodies are very diverse and reflect their ability to engage in antibody-dependent effector mechanisms, internalize to deliver cytotoxic payloads, and display direct effects on cells by lysis or by modulating the biological pathways of their target antigens. Importantly, one of the universal changes in cancer is glycosylation and carbohydrate-binding antibodies can be produced to selectively recognize tumor cells over normal tissues. A promising group of cell surface antibody targets consists of carbohydrates presented as glycolipids or glycoproteins. In this review, we outline the basic principles of antibody-based targeting of carbohydrate antigens in cancer. We also present a detailed structural view of antibody recognition and the conformational properties of a series of related tissue-blood group (Lewis) carbohydrates that are being pursued as potential targets of cancer immunotherapy.
Showing items related by title, author, creator and subject.
Agostino, Mark; Farrugia, W.; Sandrin, M.; Scott, A.; Yuriev, E.; Ramsland, Paul (2012)Carbohydrate antigens recognized by “natural” or preformed and elicited antibodies are central to transplantation/transfusion rejection across ABO blood group and species (xenotransplantation) barriers and are also promising ...
Antibody Recognition of Cancer-Related Gangliosides and Their Mimics Investigated Using in silico Site MappingAgostino, Mark; Yuriev, E.; Ramsland, Paul (2012)Modified gangliosides may be overexpressed in certain types of cancer, thus, they are considered a valuable target in cancer immunotherapy. Structural knowledge of their interaction with antibodies is currently limited, ...
Molecular docking of carbohydrate ligands to antibodies: Structural validation against crystal structuresAgostillo, M.; Jene, C.; Boyle, T.; Ramsland, Paul; Yuriev, E. (2009)Cell surface glycoproteins play vital roles in cellular homeostasis and disease. Antibody recognition of glycosylation on different cells and pathogens is critically important for immune surveillance. Conversely, adverse ...