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dc.contributor.authorLe Page, M.
dc.contributor.authorGoodridge, J.
dc.contributor.authorZhang, Guicheng
dc.contributor.authorHolt, P.
dc.contributor.authorSly, P.
dc.contributor.authorWitt, C.
dc.date.accessioned2017-01-30T15:09:08Z
dc.date.available2017-01-30T15:09:08Z
dc.date.created2013-12-02T20:00:44Z
dc.date.issued2013
dc.identifier.citationLe Page, M.E.L. and Goodridge, J.P. and Zhang, G. and Holt, P.G. and Sly, P. and Witt, C.S. 2013. Genetic Polymorphism of KIR2DL4 (CD158d), a Putative NK Cell Receptor for HLA-G, Does Not Influence Susceptibility to Asthma. Tissue Antigens. 82: pp. 276-279.
dc.identifier.urihttp://hdl.handle.net/20.500.11937/43670
dc.identifier.doi10.1111/tan.12185
dc.description.abstract

Human leukocyte antigen (HLA)-G is upregulated on the bronchial epithelium of asthma patients and genetic polymorphism affecting expression of HLA-G has been reported to influence susceptibility to asthma. As the NK cell receptor KIR2DL4 has been reported to induce interferon gamma (IFNy) secretion when ligated with HLA-G, we postulated that the 9A/10A genetic polymorphism of KIR2DL4 which influences receptor structure may influence susceptibility to asthma. KIR2DL4 genotypes weredetermined in two cohorts of children (n=219 and n=1356) in whom total serum IgE, allergen-specific IgE, atopy, bronchial reactivity and asthma symptoms had been studied between birth and 14 years. No reproducible associations with KIR2DL4 genotype were identified, leading us to conclude that the KIR2DL4 9A/10A polymorphism has no influence on susceptibility to asthma.

dc.publisherBlackwell Munksgaard
dc.subjectatopy
dc.subjectasthma
dc.subjectKIR2DL4
dc.subjectCD158d
dc.titleGenetic Polymorphism of KIR2DL4 (CD158d), a Putative NK Cell Receptor for HLA-G, Does Not Influence Susceptibility to Asthma
dc.typeJournal Article
dcterms.source.volume82
dcterms.source.startPage276
dcterms.source.endPage279
dcterms.source.issn00012815
dcterms.source.titleTissue Antigens
curtin.department
curtin.accessStatusFulltext not available


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