The phenotype of circulating follicular-helper T cells in patients with rheumatoid arthritis defines CD200 as a potential therapeutic target
MetadataShow full item record
Rheumatoid arthritis (RA) is a systemic autoimmune disease primarily affecting synovial joints in which the development of autoantibodies represents a failure of normal tolerance mechanisms, suggesting a role for follicular helper T cells (T FH) in the genesis of autoimmunity. To determine whether quantitative or qualitative abnormalities in the circulating T FH cell population exist, we analysed by flow cytometry the number and profile of these cells in 35 patients with RA and 15 matched controls. Results were correlated with patient characteristics, including the presence of autoantibodies, disease activity, and treatment with biologic agents. Circulating T FH cells from patients with RA show significantly increased expression of the immunoglobulin superfamily receptor CD200, with highest levels seen in seropositive patients (P = 0.0045) and patients treated with anti-TNFa agents (P = 0.0008). This occurs in the absence of any change in T FH numbers or overt bias towards Th1, Th2, or Th17 phenotypes. CD200 levels did not correlate with DAS28 scores (P = 0.887). Although the number of circulating T FH cells is not altered in the blood of patients with RA, the T FH cells have a distinct phenotype. These differences associate T FH cells with the pathogenesis of RA and support the relevance of the CD200/CD200R signalling pathway as a potential therapeutic target. © 2012 Aron Chakera et al.
Showing items related by title, author, creator and subject.
Ammirati, E.; Cianflone, D.; Vecchio, V.; Banfi, M.; Vermi, A.; De Metrio, M.; Grigore, L.; Pellegatta, F.; Pirillo, A.; Garlaschelli, K.; Manfredi, A.; Catapano, A.; Maseri, A.; Palini, A.; Norata, Giuseppe (2012)Background- Adaptive T-cell response is promoted during atherogenesis and results in the differentiation of näive CD4 + T cells to effector and/or memory cells of specialized T-cell subsets. Aim of this work was to ...
Increased CTLA-4+ T cells may contribute to impaired T helper type 1 immune responses in patients with chronic obstructive pulmonary diseaseTan, D.; Teo, T.; Setiawan, A.; Ong, N.; Zimmermann, M.; Price, Patricia; Kirkham, L.; Moodley, Y. (2017)Impaired T helper type 1 (Th1) function is implicated in the susceptibility of patients with chronic obstructive pulmonary disease (COPD) to respiratory infections, which are common causes of acute exacerbations of COPD ...
Cardiometabolic and immune factors associated with increased common carotid artery intima-media thickness and cardiovascular disease in patients with systemic lupus erythematosusAmmirati, E.; Bozzolo, E.; Contri, R.; Baragetti, A.; Palini, A.; Cianflone, D.; Banfi, M.; Uboldi, P.; Bottoni, G.; Scotti, I.; Pirillo, A.; Grigore, L.; Garlaschelli, K.; Monaco, C.; Catapano, A.; Sabbadini, M.; Manfredi, A.; Norata, Giuseppe (2014)Background and aim: Patients with systemic lupus erythematosus (SLE) have a higher prevalence of subclinical atherosclerosis and higher risk of cardiovascular (CV) events compared to the general population. The relative ...