Show simple item record

dc.contributor.authorGetz, G.
dc.contributor.authorGabriel, S.
dc.contributor.authorCibulskis, K.
dc.contributor.authorLander, E.
dc.contributor.authorSivachenko, A.
dc.contributor.authorSougnez, C.
dc.contributor.authorLawrence, M.
dc.contributor.authorKandoth, C.
dc.contributor.authorDooling, D.
dc.contributor.authorFulton, R.
dc.contributor.authorFulton, L.
dc.contributor.authorKalicki-Veizer, J.
dc.contributor.authorMcLellan, M.
dc.contributor.authorO'Laughlin, M.
dc.contributor.authorSchmidt, H.
dc.contributor.authorWilson, R.
dc.contributor.authorYe, K.
dc.contributor.authorLi, D.
dc.contributor.authorAlly, A.
dc.contributor.authorBalasundaram, M.
dc.contributor.authorBirol, I.
dc.contributor.authorButterfield, Y.
dc.contributor.authorCarlsen, R.
dc.contributor.authorCarter, C.
dc.contributor.authorChu, A.
dc.contributor.authorChuah, E.
dc.contributor.authorChun, H.
dc.contributor.authorDhalla, N.
dc.contributor.authorGuin, R.
dc.contributor.authorHirst, C.
dc.contributor.authorHolt, R.
dc.contributor.authorJones, S.
dc.contributor.authorLee, D.
dc.contributor.authorLi, H.
dc.contributor.authorMarra, M.
dc.contributor.authorMayo, M.
dc.contributor.authorMoore, R.
dc.contributor.authorMungall, A.
dc.contributor.authorPlettner, P.
dc.contributor.authorSchein, J.
dc.contributor.authorSipahimalani, P.
dc.contributor.authorTam, A.
dc.contributor.authorVarhol, Richard
dc.contributor.authorGordon Robertson, A.
dc.contributor.authorCherniack, A.
dc.contributor.authorPashtan, I.
dc.contributor.authorSaksena, G.
dc.contributor.authorOnofrio, R.
dc.contributor.authorSchumacher, S.
dc.contributor.authorTabak, B.
dc.contributor.authorCarter, S.
dc.contributor.authorHernandez, B.
dc.contributor.authorGentry, J.
dc.contributor.authorSalvesen, H.
dc.contributor.authorArdlie, K.
dc.contributor.authorWinckler, W.
dc.contributor.authorBeroukhim, R.
dc.contributor.authorMeyerson, M.
dc.contributor.authorHadjipanayis, A.
dc.contributor.authorLee, S.
dc.contributor.authorMahadeshwar, H.
dc.contributor.authorPark, P.
dc.contributor.authorProtopopov, A.
dc.contributor.authorRen, X.
dc.contributor.authorSeth, S.
dc.contributor.authorSong, X.
dc.contributor.authorTang, J.
dc.contributor.authorXi, R.
dc.contributor.authorYang, L.
dc.contributor.authorDong, Z.
dc.contributor.authorKucherlapati, R.
dc.contributor.authorChin, L.
dc.contributor.authorZhang, J.
dc.contributor.authorTodd Auman, J.
dc.contributor.authorBalu, S.
dc.contributor.authorBodenheimer, T.
dc.contributor.authorBuda, E.
dc.contributor.authorNeil Hayes, D.
dc.contributor.authorHoyle, A.
dc.contributor.authorJefferys, S.
dc.contributor.authorJones, C.
dc.contributor.authorMeng, S.
dc.contributor.authorMieczkowski, P.
dc.contributor.authorMose, L.
dc.contributor.authorParker, J.
dc.contributor.authorPerou, C.
dc.date.accessioned2017-01-30T15:11:16Z
dc.date.available2017-01-30T15:11:16Z
dc.date.created2016-02-01T00:47:10Z
dc.date.issued2013
dc.identifier.citationGetz, G. and Gabriel, S. and Cibulskis, K. and Lander, E. and Sivachenko, A. and Sougnez, C. and Lawrence, M. et al. 2013. Integrated genomic characterization of endometrial carcinoma. Nature. 497 (7447): pp. 67-73.
dc.identifier.urihttp://hdl.handle.net/20.500.11937/43955
dc.identifier.doi10.1038/nature12113
dc.description.abstract

We performed an integrated genomic, transcriptomic and proteomic characterization of 373 endometrial carcinomas using array-and sequencing-based technologies. Uterine serous tumours and ~25% of high-grade endometrioid tumours had extensive copy number alterations, few DNA methylation changes, low oestrogen receptor/progesterone receptor levels, and frequent TP53 mutations. Most endometrioid tumours had few copy number alterations or TP53 mutations, but frequent mutations in PTEN, CTNNB1, PIK3CA, ARID1A and KRAS and novel mutations in the SWI/SNF chromatin remodelling complex gene ARID5B. A subset of endometrioid tumours that we identified had a markedly increased transversion mutation frequency and newly identified hotspot mutations in POLE. Our results classified endometrial cancers into four categories: POLE ultramutated, microsatellite instability hypermutated, copy-number low, and copy-number high. Uterine serous carcinomas share genomic features with ovarian serous and basal-like breast carcinomas. We demonstrated that the genomic features of endometrial carcinomas permit a reclassification that may affect post-surgical adjuvant treatment for women with aggressive tumours. © 2013 Macmillan Publishers Limited. All rights reserved.

dc.titleIntegrated genomic characterization of endometrial carcinoma
dc.typeJournal Article
dcterms.source.volume497
dcterms.source.number7447
dcterms.source.startPage67
dcterms.source.endPage73
dcterms.source.issn0028-0836
dcterms.source.titleNature
curtin.note

This open access article is distributed under the Creative Commons license http://creativecommons.org/licenses/by-nc-sa/3.0/

curtin.departmentDepartment of Health Policy and Management
curtin.accessStatusOpen access


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record