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dc.contributor.authorLang, I.
dc.contributor.authorGalloway, T.
dc.contributor.authorScarlett, Alan
dc.contributor.authorHenley, W.
dc.contributor.authorDepledge, M.
dc.contributor.authorWallace, R.
dc.contributor.authorMelzer, D.
dc.date.accessioned2017-01-30T15:11:32Z
dc.date.available2017-01-30T15:11:32Z
dc.date.created2016-09-12T08:37:00Z
dc.date.issued2008
dc.identifier.citationLang, I. and Galloway, T. and Scarlett, A. and Henley, W. and Depledge, M. and Wallace, R. and Melzer, D. 2008. Association of Urinary Bisphenol A concentration with medical disorders and laboratory abnormalities in adults. JAMA - Journal of the American Medical Association. 300 (11): pp. 1303-1310.
dc.identifier.urihttp://hdl.handle.net/20.500.11937/44015
dc.identifier.doi10.1001/jama.300.11.1303
dc.description.abstract

Context: Bisphenol A (BPA) is widely used in epoxy resins lining food and beverage containers. Evidence of effects in animals has generated concern over low-level chronic exposures in humans. Objective: To examine associations between urinary BPA concentrations and adult health status. Design, Setting, and Participants: Cross-sectional analysis of BPA concentrations and health status in the general adult population of the United States, using data from the National Health and Nutrition Examination Survey 2003-2004. Participants were 1455 adults aged 18 through 74 years with measured urinary BPA and urine creatinine concentrations. Regression models were adjusted for age, sex, race/ ethnicity, education, income, smoking, body mass index, waist circumference, and urinary creatinine concentration. The sample provided 80% power to detect unadjusted odds ratios (ORs) of 1.4 for diagnoses of 5% prevalence per 1-SD change in BPA concentration, or standardized regression coefficients of 0.075 for liver enzyme concentrations, at a significance level of P<.05. Main Outcome Measures: Chronic disease diagnoses plus blood markers of liver function, glucose homeostasis, inflammation, and lipid changes. Results: Higher urinary BPA concentrations were associated with cardiovascular diagnoses in age-, sex-, and fully adjusted models (OR per 1-SD increase in BPA concentration, 1.39; 95% confidence interval [CI], 1.18-1.63; P=.001 with full adjustment). Higher BPA concentrations were also associated with diabetes (OR per 1-SD increase in BPA concentration, 1.39; 95% confidence interval [CI], 1.21-1.60; P<.001) but not with other studied common diseases. In addition, higher BPA concentrations were associated with clinically abnormal concentrations of the liver enzymes ?-glutamyltransferase (OR per 1-SD increase in BPA concentration, 1.29;95%CI, 1.14-1.46; P<.001) and alkaline phosphatase (OR per 1-SD increase in BPA concentration, 1.48; 95% CI, 1.18-1.85; P=.002). Conclusion: Higher BPA exposure, reflected in higher urinary concentrations of BPA, may be associated with avoidable morbidity in the community-dwelling adult population. ©2008 American Medical Association. All rights reserved.

dc.titleAssociation of Urinary Bisphenol A concentration with medical disorders and laboratory abnormalities in adults
dc.typeJournal Article
dcterms.source.volume300
dcterms.source.number11
dcterms.source.startPage1303
dcterms.source.endPage1310
dcterms.source.issn0098-7484
dcterms.source.titleJAMA - Journal of the American Medical Association
curtin.accessStatusOpen access via publisher


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