Genetic and epigenetic regulation of phosphoinositide 3-kinase isoforms
MetadataShow full item record
The last quarter of a century has witnessed remarkable progress in the understanding of phosphoinositide 3-kinases (PI3K) signalling and their involvement in different diseases such as cancer, diabetes and inflammation. Nevertheless, many questions remain open and among these the role of genetic and epigenetic regulation of PI3K isoforms is one of the most prominent. Emerging evidence Indicates that levels of isoforms can be modulated upon stimulation or in both physiological and pathological conditions including increased gene copy number and transcription regulation. In addition, an intriguing role for epigenetic regulation of PI3K expression, caused by mechanisms other than changes in the underlying DNA sequence, are starting to get appreciated. In this review, we summarize the genetic and epigenetic regulation of PI3Ks in physiology and the role played by their alterations in different diseases.
Showing items related by title, author, creator and subject.
Shanmugam, M.; Arfuso, Frank; Arumugam, S.; Chinnathambi, A.; Jinsong, B.; Warrier, Sudha; Wang, L.; Kumar, A.; Ahn, K.; Sethi, G.; Lakshmanan, M. (2018)© Shanmugam et al. Oncogenesis is a multistep process mediated by a variety of factors including epigenetic modifications. Global epigenetic post-translational modifications have been detected in almost all cancers types. ...
Moheimani, F.; Hsu, A.; Reid, A.; Williams, T.; Kicic, Anthony; Stick, S.; Hansbro, P.; Wark, P.; Knight, D. (2016)© 2016 The Author(s). Asthma is a global health problem with increasing prevalence. The airway epithelium is the initial barrier against inhaled noxious agents or aeroallergens. In asthma, the airway epithelium suffers ...
Epigenetic reprogramming converts human Wharton's jelly mesenchymal stem cells into functional cardiomyocytes by differential regulation of Wnt mediatorsBhuvanalakshmi, G.; Arfuso, Frank; Kumar, Alam Prem; Dharmarajan, Arunasalam; Warrier, Sudha (2017)BACKGROUND: Lineage commitment of mesenchymal stem cells (MSCs) to cardiac differentiation is controlled by transcription factors that are regulated by epigenetic events, mainly histone deacetylation and promoter DNA ...