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    Intraoperative Assessment of Margins in Breast Conserving Therapy: A Systematic review

    Access Status
    Fulltext not available
    Authors
    Butler-Henderson, K.
    Lee, Andy
    Price, R.
    Waring, K.
    Date
    2014
    Type
    Journal Article
    
    Metadata
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    Citation
    Butler-Henderson, K. and Lee, A. and Price, R. and Waring, K. 2014. Intraoperative Assessment of Margins in Breast Conserving Therapy: A Systematic review. The Breast. 23 (2): pp. 112-119.
    Source Title
    The Breast
    DOI
    10.1016/j.breast.2014.01.002
    ISSN
    09609776
    URI
    http://hdl.handle.net/20.500.11937/4446
    Collection
    • Curtin Research Publications
    Abstract

    Approximately one quarter of patients undergoing breast conserving therapy for breast cancer will require a second operation to achieve adequate clearance of the margins. A number of techniques to assess margins intraoperatively have been reported. This systematic review examines current intraoperative methods for assessing margin status. The final pathology status, statistical measures including accuracy of tumour margin assessment, average time impact on the procedure and second operation rate, were used as criteria for comparison between studies. Although pathological methods, such as frozen section and imprint cytology performed well, they added on average 20e30 min to operation times. An ultrasound probe allows accurate examination of the margins and delivers results in a timely manner, yet it has a limited role with DCIS where calcification is present and in multifocal cancer. Further research is required in other intraoperative margin assessment techniques, such as mammography, radiofrequency spectroscopy and optical coherence tomography.

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