Intraoperative Assessment of Margins in Breast Conserving Therapy: A Systematic review
MetadataShow full item record
Approximately one quarter of patients undergoing breast conserving therapy for breast cancer will require a second operation to achieve adequate clearance of the margins. A number of techniques to assess margins intraoperatively have been reported. This systematic review examines current intraoperative methods for assessing margin status. The final pathology status, statistical measures including accuracy of tumour margin assessment, average time impact on the procedure and second operation rate, were used as criteria for comparison between studies. Although pathological methods, such as frozen section and imprint cytology performed well, they added on average 20e30 min to operation times. An ultrasound probe allows accurate examination of the margins and delivers results in a timely manner, yet it has a limited role with DCIS where calcification is present and in multifocal cancer. Further research is required in other intraoperative margin assessment techniques, such as mammography, radiofrequency spectroscopy and optical coherence tomography.
Showing items related by title, author, creator and subject.
Theoretical versus Ex Vivo Assessment of Radiation Damage Repair: An Investigation in Normal Breast TissueEbert, M.; Dhal, B.; Prunster, J.; McLaren, S.; Zeps, Nikolajs; House, M.; Reniers, B.; Verhaegen, F.; Corica, T.; Saunders, C.; Joseph, D. (2016)In vivo validation of models of DNA damage repair will enable their use for optimizing clinical radiotherapy. In this study, a theoretical assessment was made of DNA double-strand break (DSB) induction in normal breast ...
Quantitative Measurements of Breast Density Using Magnetic Resonance Imaging: A Systematic Review and Meta-AnalysisSindi, Rooa; Sa dos Reis, Claudia; Bennett, Colleen; Stevenson, G.; Sun, Zhonghua (2019)Breast density, a measure of dense fibroglandular tissue relative to non-dense fatty tissue, is confirmed as an independent risk factor of breast cancer. Although there has been an increasing interest in the quantitative ...
Detection of breast cancer with ultrasound tomography: First results with the Computed Ultrasound Risk Evaluation (CURE) prototypeDuric, N.; Littrup, P.; Poulo, L.; Babkin, A.; Pevzner, Roman; Holsapple, E.; Rama, O.; Glide, C. (2007)Although mammography is the gold standard for breast imaging, its limitations result in a high rate of biopsies of benign lesions and a significant false negative rate for women with dense breasts. In response to this ...