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    Phenotyping airway disease with optical coherence tomography

    Access Status
    Open access via publisher
    Authors
    Coxson, H.
    Eastwood, Peter
    Williamson, J.
    Sin, D.
    Date
    2011
    Type
    Journal Article
    
    Metadata
    Show full item record
    Citation
    Coxson, H. and Eastwood, P. and Williamson, J. and Sin, D. 2011. Phenotyping airway disease with optical coherence tomography. Respirology. 16 (1): pp. 34-43.
    Source Title
    Respirology
    DOI
    10.1111/j.1440-1843.2010.01888.x
    ISSN
    1323-7799
    School
    School of Physiotherapy and Exercise Science
    URI
    http://hdl.handle.net/20.500.11937/44590
    Collection
    • Curtin Research Publications
    Abstract

    Airway diseases are amajor concern around the world. However, the pace of new drug and biomarker discovery has lagged behind those of other common disorders such as cardiovascular diseases and diabetes. One major barrier in airway research has been the inability to accurately visualize large or small airway remodelling or dysplastic/neoplastic (either pre or early cancerous) changes using non- or minimally invasive instruments. The advent of optical coherence tomography (OCT) has the potential to revolutionize airway research and management by allowing investigators and clinicians to visualize the airway with resolution approaching histology and without exposing patients to harmful effects of ionizing radiation. Thus, with the aid of OCT,we may be able to accurately determine and quantify the extent of airway remodelling in asthma and chronic obstructive pulmonary disease, detect early pre-cancerous lesions in smokers for chemoprevention, study the upper airway anatomy of patients with obstructive sleep apnea in real time while they are asleep and facilitate optimal selection of stents for those with tracheal obstruction. In this paper, we review the current state of knowledge of OCT and its possible application in airway diseases. © 2010 The Author Journal compilation © 2010 Asian Pacific Society of Respirology.

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