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    Photoluminescent carbon dots as biocompatible nanoprobes for targeting cancer cells in vitro

    Access Status
    Fulltext not available
    Authors
    Li, Qin
    Ohulchanskyy, T.
    Liu, R.
    Koynov, K.
    Wu, D.
    Best, A.
    Kumar, R.
    Bonoiu, A.
    Prasad, P.
    Date
    2010
    Type
    Journal Article
    
    Metadata
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    Citation
    Li, Q. and Ohulchanskyy, T. and Liu, R. and Koynov, K. and Wu, D. and Best, A. and Kumar, R. et al. 2010. Photoluminescent carbon dots as biocompatible nanoprobes for targeting cancer cells in vitro. Journal of Physical Chemistry C. 114 (28): pp. 12062-12068.
    Source Title
    Journal of Physical Chemistry C
    DOI
    10.1021/jp911539r
    ISSN
    1932-7447
    School
    Department of Chemical Engineering
    URI
    http://hdl.handle.net/20.500.11937/44638
    Collection
    • Curtin Research Publications
    Abstract

    Carbon nanoparticles become photoluminescent upon surface passivation with oligomeric polymer chains. In this work, the dependence of the carbon dots photoluminescent properties on the passivation polymer selection has been demonstrated by conjugating polyethylene glycol (PEG) chains, polyethylenimide-co-polyethylene glycol-co-polyethylenimide copolymer, and 4-armed PEG molecules, respectively. The cytotoxicity and cellular internalization of the resulting three types of photoluminescent nanoformulations of carbon dots, named CD2, CD3, and CD4, were evaluated. These nanoformulations exhibited no apparent cytotoxicity on their own and were shown to successfully target cancer cells by conjugation with transferrin. The implication to the use of carbon dots as biocompatible optical nanoprobes for in vitro cancer diagnostics is discussed.

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