Photoluminescent carbon dots as biocompatible nanoprobes for targeting cancer cells in vitro
MetadataShow full item record
Carbon nanoparticles become photoluminescent upon surface passivation with oligomeric polymer chains. In this work, the dependence of the carbon dots photoluminescent properties on the passivation polymer selection has been demonstrated by conjugating polyethylene glycol (PEG) chains, polyethylenimide-co-polyethylene glycol-co-polyethylenimide copolymer, and 4-armed PEG molecules, respectively. The cytotoxicity and cellular internalization of the resulting three types of photoluminescent nanoformulations of carbon dots, named CD2, CD3, and CD4, were evaluated. These nanoformulations exhibited no apparent cytotoxicity on their own and were shown to successfully target cancer cells by conjugation with transferrin. The implication to the use of carbon dots as biocompatible optical nanoprobes for in vitro cancer diagnostics is discussed.
Showing items related by title, author, creator and subject.
Size dependence of uniformed carbon spheres in promoting graphitic carbon nitride toward enhanced photocatalysisLiu, S.; Ke, J.; Sun, Hongqi; Liu, Jian; Tade, Moses; Wang, Shaobin (2017)Recently, graphitic carbon nitride (GCN) has been extensively employed as a metal-free, visible-light-responsive photocatalyst. The strong recombination rate of photo-induced charges and small surface area limit its wide ...
Integrated oxygen-doping and dye sensitization of graphitic carbon nitride for enhanced visible light photodegradationLiu, S.; Sun, Hongqi; Ang, H.; Tade, Moses; Wang, Shaobin (2016)Graphitic carbon nitride (GCN) is a promising metal-free photocatalyst while suffering from low charge mobility induced inefficient photocatalysis. In this work, oxygen doping was employed to enhance the photodegradation ...
Grove, C.; Rodriguez-Ramirez, A.; Merschel, G.; Tjallingii, R.; Zinke, Jens; Macia, A.; Brummer, G. (2015)Spectral luminescence scanning (SLS) is a novel technique that uses a UV light source and line-scan camera to generate photoluminescence images of carbonate materials, such as corals. The camera in the Avaatech XRF core ...