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dc.contributor.authorLim, F.
dc.contributor.authorKow, K.
dc.contributor.authorYeo, E.
dc.contributor.authorChow, S.
dc.contributor.authorDolzhenko, Anton
dc.date.accessioned2017-01-30T15:15:35Z
dc.date.available2017-01-30T15:15:35Z
dc.date.created2016-07-13T19:30:16Z
dc.date.issued2016
dc.identifier.citationLim, F. and Kow, K. and Yeo, E. and Chow, S. and Dolzhenko, A. 2016. Synthesis and Antileukemic Activity of New Fluorinated 5-Aza-9-deazapurines. Heterocycles. 92 (6): pp. 1121-1131.
dc.identifier.urihttp://hdl.handle.net/20.500.11937/44647
dc.identifier.doi10.3987/COM-16-13464
dc.description.abstract

Novel fluorinated 4-benzylamino-7-phenylpyrazolo[1,5-a]- [1,3,5]triazin-2-amines were prepared using an efficient and practical approach. The chemoselectivity of condensation of pyrazolylguanidine and trichloroacetonitrile was found to be solvent-dependent and, when conducted in toluene, this reaction afforded 7-phenyl-4-trichloromethylpyrazolo[1,5-a]- [1,3,5]triazin-2-amine as the main product. This key intermediate underwent nucleophilic replacement of the trichloromethyl group with fluorinated benzylamines providing a series of the target compounds. Antiproliferative activity of the prepared compounds against Jurkat T cells was explored using MTS assay. Morphological changes observed in cells treated by the most potent compounds of this series, suggested that these compounds induced apoptosis in cells.

dc.publisherThe Japan Institute of Heterocyclic Chemistry
dc.titleSynthesis and Antileukemic Activity of New Fluorinated 5-Aza-9-deazapurines
dc.typeJournal Article
dcterms.source.volume92
dcterms.source.number6
dcterms.source.startPage1121
dcterms.source.endPage1131
dcterms.source.issn0385-5414
dcterms.source.titleHeterocycles
curtin.departmentSchool of Pharmacy
curtin.accessStatusFulltext not available


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