Curtin University Homepage
  • Library
  • Help
    • Admin

    espace - Curtin’s institutional repository

    JavaScript is disabled for your browser. Some features of this site may not work without it.
    View Item 
    • espace Home
    • espace
    • Curtin Research Publications
    • View Item
    • espace Home
    • espace
    • Curtin Research Publications
    • View Item

    Preclinical assessment of adjunctive tPA and DNase for peritoneal dialysis associated peritonitis

    Access Status
    Open access via publisher
    Authors
    McGuire, A.
    Bennett, S.
    Lansley, S.
    Popowicz, N.
    Della Vergiliana, J.
    Wong, D.
    Lee, Y.
    Chakera, Aron
    Date
    2015
    Type
    Journal Article
    
    Metadata
    Show full item record
    Citation
    McGuire, A. and Bennett, S. and Lansley, S. and Popowicz, N. and Della Vergiliana, J. and Wong, D. and Lee, Y. et al. 2015. Preclinical assessment of adjunctive tPA and DNase for peritoneal dialysis associated peritonitis. PLoS ONE. 10 (3).
    Source Title
    PLoS ONE
    DOI
    10.1371/journal.pone.0119238
    School
    Curtin Medical School
    URI
    http://hdl.handle.net/20.500.11937/44657
    Collection
    • Curtin Research Publications
    Abstract

    Copyright: #x000a9; 2015 McGuire et al. A major complication of peritoneal dialysis is the development of peritonitis, which is associated with reduced technique and patient survival. The inflammatory response elicited by infection results in a fibrin and debris-rich environment within the peritoneal cavity, which may reduce the effectiveness of antimicrobial agents and predispose to recurrence or relapse of infection. Strategies to enhance responses to antimicrobial agents therefore have the potential to improve patient outcomes. This study presents pre-clinical data describing the compatibility of tPA and DNase in combination with antimicrobial agents used for the treatment of PD peritonitis. tPA and DNase were stable in standard dialysate solution and in the presence of antimicrobial agents, and were safe when given intraperitoneally in a mouse model with no evidence of local or systemic toxicity. Adjunctive tPA and DNase may have a role in the management of patients presenting with PD peritonitis.

    Related items

    Showing items related by title, author, creator and subject.

    • Effects of a statewide protocol for the management of peritoneal dialysis-related peritonitis on microbial profiles and antimicrobial susceptibilities: A retrospective five-year review
      McGuire, A.; Carson, C.; Inglis, T.; Chakera, Aron (2015)
      Background: Peritonitis is a major complication of peritoneal dialysis (PD) and is associated with significant morbidity and mortality. Early empirical antibiotic therapy is recommended, with the choice of agents guided ...
    • In vitro data support the investigation of vinegar as an antimicrobial agent for PD-associated Pseudomonas exit site infections
      Carson, C.; Ash, O.; Chakera, Aron (2017)
      © 2017 Asian Pacific Society of NephrologyPeritoneal dialysis exit site infections caused by Pseudomonas spp. are difficult to treat and can lead to peritonitis and/or modality failure. Effective alternative or adjunct ...
    • Nanoformulation and Application of Phytochemicals as Antimicrobial Agents
      Jeevanandam, J.; Aing, Y.; Chan, Stephanie; Pan, S.; Danquah, M. (2017)
      Plants are a major source of medicine from which most drug compounds emanate. Therapeutic phytochemicals have been used as model candidates for the synthesis of chemical drugs and pharmaceuticals. Recent increase in ...
    Advanced search

    Browse

    Communities & CollectionsIssue DateAuthorTitleSubjectDocument TypeThis CollectionIssue DateAuthorTitleSubjectDocument Type

    My Account

    Admin

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular Authors

    Follow Curtin

    • 
    • 
    • 
    • 
    • 

    CRICOS Provider Code: 00301JABN: 99 143 842 569TEQSA: PRV12158

    Copyright | Disclaimer | Privacy statement | Accessibility

    Curtin would like to pay respect to the Aboriginal and Torres Strait Islander members of our community by acknowledging the traditional owners of the land on which the Perth campus is located, the Whadjuk people of the Nyungar Nation; and on our Kalgoorlie campus, the Wongutha people of the North-Eastern Goldfields.