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    Wiring cost and topological participation of the mouse brain connectome

    Access Status
    Open access via publisher
    Authors
    Rubinov, M.
    Ypma, R.
    Watson, Charles
    Bullmore, E.
    Date
    2015
    Type
    Journal Article
    
    Metadata
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    Citation
    Rubinov, M. and Ypma, R. and Watson, C. and Bullmore, E. 2015. Wiring cost and topological participation of the mouse brain connectome. Proceedings of the National Academy of Sciences. 112 (32): pp. 10032-10037.
    Source Title
    Proceedings of the National Academy of Sciences of the United of States of America
    DOI
    10.1073/pnas.1420315112
    ISSN
    1091-6490
    Faculty
    Faculty of Health Sciences
    URI
    http://hdl.handle.net/20.500.11937/44984
    Collection
    • Curtin Research Publications
    Abstract

    Brain connectomes are topologically complex systems, anatomically embedded in 3D space. Anatomical conservation of “wiring cost” explains many but not all aspects of these networks. Here, we examined the relationship between topology and wiring cost in the mouse connectome by using data from 461 systematically acquired anterograde- tracer injections into the right cortical and subcortical regions of the mouse brain. We estimated brain-wide weights, distances, and wiring costs of axonal projections and performed a multiscale topological and spatial analysis of the resulting weighted and directed mouse brain connectome. Our analysis showed that the mouse connectome has small-world properties, a hierarchical modular structure, and greater-than-minimalwiring costs. High-participation hubs of this connectome mediated communication between functionally specialized and anatomically localized modules, had especially high wiring costs, and closely corresponded to regions of the default mode network. Analyses of independently acquired histological and geneexpression data showed that nodal participation colocalized with low neuronal density and high expression of genes enriched for cognition, learning and memory, and behavior. The mouse connectome contains high-participation hubs, which are not explained by wiring-cost minimization but instead reflect competitive selection pressures for integrated network topology as a basis for higher cognitive and behavioral functions.

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