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    Role of Wnt signalling in early pregnancy

    Access Status
    Fulltext not available
    Authors
    Nayeem, S.
    Arfuso, Frank
    Dharmarajan, Arunasalam
    Keelan, J.
    Date
    2015
    Type
    Journal Article
    
    Metadata
    Show full item record
    Citation
    Nayeem, S. and Arfuso, F. and Dharmarajan, A. and Keelan, J. 2015. Role of Wnt signalling in early pregnancy. Reproduction, Fertility and Development. 28 (5): pp. 525-544.
    Source Title
    Reproduction, Fertility and Development
    DOI
    10.1071/RD14079
    ISSN
    1031-3613
    School
    School of Biomedical Sciences
    URI
    http://hdl.handle.net/20.500.11937/45476
    Collection
    • Curtin Research Publications
    Abstract

    The integration of a complex network of signalling molecules promotes implantation of the blastocyst and development of the placenta. These processes are crucial for a successful pregnancy and fetal growth and development. The signalling network involves both cell–cell and cell–extracellular matrix communication. The family of secreted glycoprotein ligands, the Wnts, plays a major role in regulating a wide range of biological processes, including embryonic development, cell fate, proliferation, migration, stem cell maintenance, tumour suppression, oncogenesis and tissue homeostasis. Recent studies have provided evidence that Wnt signalling pathways play an important role in reproductive tissues and in early pregnancy events. The focus of this review is to summarise our present knowledge of expression, regulation and function of the Wnt signalling pathways in early pregnancy events of human and other model systems, and its association with pathological conditions. Despite our recent progress, much remains to be learned about Wnt signalling in human reproduction. The advancement of knowledge in this area has applications in the reduction of infertility and the incidence and morbidity of gestational diseases.

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