Calcium channel blocker associated lower urinary tract symptoms in males: an Australian retrospective observational study
MetadataShow full item record
BACKGROUND: Lower urinary tract symptoms (LUTS) are common and prevalence increases with age. In men, voiding symptoms are more commonly encountered than storage symptoms. LUTS are often associated with chronic diseases but their pathophysiology requires further study. We aimed to determine whether calcium channel blockers (CCBs) worsened, improved or did not alter symptoms of urinary obstruction in males aged 45 years and above with medical conditions associated with urinary obstruction. METHODS: A cohort retrospective observational study was undertaken to identify the effect of the use of CCBs on LUTS in males over 45 years of age. Participants were recruited from four community pharmacies and a general practitioner surgery. Eligible participants provided informed consent and were administered a standardised questionnaire (IPSS) to obtain information on LUTS and quality of life (QOL) prior to and after commencement of CCB therapy. RESULTS: Thirty-eight males were enrolled in the study, and their ages of ranged from 46.2 to 88.7 years, with the mean age being 66.9 years (95% CI: 63.9-69.9). The mean IPPS score prior to commencing a CCB was 3.13 (95% CI: 2.09-4.17) compared to 9.82 (95% CI: 7.83-11.80) whilst on the drug (P<0.001). After adjusting for other medications and conditions which may contribute to LUTS, and for the natural progression of LUTS with ageing, the change remained significant. The increase in IPPS score was associated with a significant decline in the respondents' QOL.CONCLUSION: The results of this study suggest that in middle-aged males the introduction of a CCB may be associated with worsening of LUTS, and an associated decline in QOL, although this will need to be confirmed in large prospective studies. However, given the common use of these agents in males to treat a range of cardiovascular conditions, we would suggest that men prescribed a CCB should be questioned about urinary symptoms before and after commencing treatment.
Showing items related by title, author, creator and subject.
Elhebir, Elsamaul Suliman A. (2011)Lower urinary tract symptoms (LUTS) are a group of obstructive and irritative urinary symptoms. These include storage, voiding, and post-micturition symptoms. LUTS are prevalent and bothersome in the rapidly growing ageing ...
Effectiveness of educational interventions to raise men's awareness of bladder and bowel health: a systematic reviewHodgkinson, B.; Tuckett, A.; Hegney, Desley; Paterson, J.; Kralik, D. (2010)Background: Urinary incontinence (UI) has been defined as a condition in which the involuntary loss of urine is a social or hygienic problem and is objectively demonstrable. Urinary incontinence is a common health problem ...
Modelling the co-occurence of Streptococcus pneumoniae with other bacterial and viral pathogens in the upper respiratory tractJacoby, P.; Watson, K.; Bowman, J.; Taylor, A.; Riley, T.; Smith, D.; Lehmann, Deborah (2007)Go to ScienceDirect® Home Skip Main Navigation Links Brought to you by: The University of Western Australia Library Login: + Register Athens/Institution Login Not Registered? - User Name: Password: ...